Sup45p

{{Update|date=December 2024|reason=Needs updating to fit current MOS}}

Sup45p is the Saccharomyces cerevisiae (a yeast) eukaryotic translation termination factor. More specifically, it is the yeast eukaryotic release factor 1 (eRF1). Its job is to recognize stop codons in RNA and bind to them. It binds to the Sup35p protein and then takes on the shape of a tRNA molecule so that it can safety incorporate itself into the A site of the Ribosome to disruptits flow and "release" the protein and end translation.{{Cite journal

| last1 = Paushkin | first1 = S. V.

| last2 = Kushnirov | first2 = V. V.

| last3 = Smirnov | first3 = V. N.

| last4 = Ter-Avanesyan | first4 = M. D.

| title = Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: Implications for prion-dependent regulation

| journal = Molecular and Cellular Biology

| volume = 17

| issue = 5

| pages = 2798–2805

| year = 1997

| pmid = 9111351

| pmc = 232131 | doi=10.1128/mcb.17.5.2798

}}