Sweat allergy

{{Short description|Skin inflammation caused by sweat}}

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| specialty = dermatology

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| causes =increases in the production of sweat.

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| treatment =Tannic acid, showering

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A sweat allergy is the exacerbation of atopic dermatitis associated with an elevated body temperature and resulting increases in the production of sweat. It appears as small reddish welts that become visible in response to increased temperature and resulting production of sweat.{{cite journal | vauthors = Kan T, Hiragun T, Ishii K, Hiragun M, Yanase Y, Tanaka A, Hide M | title = Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy | journal = Allergology International | volume = 64 | issue = 3 | pages = 266–271 | date = July 2015 | pmid = 26117259 | doi = 10.1016/j.alit.2015.03.003 | doi-access = free }} It can affect all ages. Sweating can trigger intense itching or cholinergic urticaria. The protein MGL_1304 secreted by mycobiota (fungi) present on the skin such as Malassezia globosa acts as a histamine or antigen. People can be desensitized using their own samples of sweat that have been purified that contains small amounts of the allergen.{{cite journal | vauthors = Hiragun T, Hiragun M, Ishii K, Kan T, Hide M | title = Sweat allergy: Extrinsic or intrinsic? | journal = Journal of Dermatological Science | volume = 87 | issue = 1 | pages = 3–9 | date = July 2017 | pmid = 28416076 | doi = 10.1016/j.jdermsci.2017.03.002 | doi-access = free }}{{cite journal | vauthors = Hiragun T, Hide M | title = Sweat Allergy | language = english | journal = Current Problems in Dermatology | volume = 51 | pages = 101–108 | date = 2016 | pmid = 27584969 | doi = 10.1159/000446788 | publisher = Karger Publishers | isbn = 978-3-318-05904-5 }} The allergy is not due to the sweat itself but instead to an allergy-producing protein secreted by microorganisms found on the skin.{{cite book | vauthors = Yokozeki H | title = Perspiration research | publisher = Karger | location = Basel New York | year = 2016 | isbn = 9783318059052 | page = 52}}

Cholinergic urticaria (CU) is one of the physical urticaria (hives) which is provoked during sweating events such as exercise, bathing, staying in a heated environment, or emotional stress. The hives produced are typically smaller than classic hives and are generally shorter-lasting.{{cite journal | vauthors = Moore-Robinson M, Warin RP | title = Some clinical aspects of cholinergic urticaria | journal = The British Journal of Dermatology | volume = 80 | issue = 12 | pages = 794–799 | date = December 1968 | pmid = 5706797 | doi = 10.1111/j.1365-2133.1968.tb11948.x | s2cid = 58415911 }}{{cite journal | vauthors = Hirschmann JV, Lawlor F, English JS, Louback JB, Winkelmann RK, Greaves MW | title = Cholinergic urticaria. A clinical and histologic study | journal = Archives of Dermatology | volume = 123 | issue = 4 | pages = 462–467 | date = April 1987 | pmid = 3827277 | doi = 10.1001/archderm.1987.01660280064024 }}

Multiple subtypes have been elucidated, each of which require distinct treatment.{{cite journal | vauthors = Nakamizo S, Egawa G, Miyachi Y, Kabashima K | title = Cholinergic urticaria: pathogenesis-based categorization and its treatment options | journal = Journal of the European Academy of Dermatology and Venereology | volume = 26 | issue = 1 | pages = 114–116 | date = January 2012 | pmid = 21371134 | doi = 10.1111/j.1468-3083.2011.04017.x | s2cid = 35802279 | url = https://zenodo.org/record/891804 | doi-access = free }}{{cite journal | vauthors = Bito T, Sawada Y, Tokura Y | title = Pathogenesis of cholinergic urticaria in relation to sweating | journal = Allergology International | volume = 61 | issue = 4 | pages = 539–544 | date = December 2012 | pmid = 23093795 | doi = 10.2332/allergolint.12-RAI-0485 | doi-access = free }}

Tannic acid has been found to suppress the allergic response, along with showering.