Systems pharmacology

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Systems pharmacology is the application of systems biology principles to the field of pharmacology. It seeks to understand how drugs affect the human body as a single complex biological system.

Instead of considering the effect of a drug to be the result of one specific drug-protein interaction, systems pharmacology considers the effect of a drug to be the outcome of the network of interactions a drug may have. In 1992, an article on systems medicine and pharmacology was published in China.Zeng (B.) J., On the holographic model of human body, 1st National Conference of Comparative Studies Traditional Chinese Medicine and West Medicine, Medicine and Philosophy, April, 1992 (termed "systems medicine and pharmacology"). Networks of interaction may include chemical-protein, protein–protein, genetic, signalling and physiological (at cellular, tissue, organ and whole body levels). Systems pharmacology uses bioinformatics and statistics techniques to integrate and interpret these networks.

Systems pharmacology can be applied to drug safety studies as a complement to pharmacoepidemiology.{{cite journal|title=Role of systems pharmacology in understanding drug adverse events|author=Seth I. Berger and Ravi Iyengar |journal=Systems Biology and Medicine|year=2011|pmid=20803507|doi=10.1002/wsbm.114|volume=3|issue=2 |pmc=3057924|pages=129–35}}