T-cell surface glycoprotein CD3 zeta chain

{{Short description|Protein-coding gene in the species Homo sapiens}}

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.{{cite journal | vauthors = Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD | title = Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 24 | pages = 9709–13 | date = December 1988 | pmid = 2974162 | pmc = 282845 | doi = 10.1073/pnas.85.24.9709 | bibcode = 1988PNAS...85.9709W | doi-access = free }}

Some older literature mention a similar protein called "CD3 eta" in mice. It is now understood to be an isoform differing in the last exon.{{cite journal | vauthors = Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL | title = CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 12 | pages = 5202–6 | date = June 1991 | pmid = 1828894 | pmc = 51840 | doi = 10.1073/pnas.88.12.5202 | doi-access = free }}

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.{{cite web | title = Entrez Gene: CD247 CD247 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=919}}

Interactions

CD247 has been shown to interact with Janus kinase 3{{cite journal | vauthors = Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T | title = Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25378–85 | date = Jul 2001 | pmid = 11349123 | doi = 10.1074/jbc.M011363200 | doi-access = free }} and Protein unc-119 homolog.{{cite journal | vauthors = Gorska MM, Stafford SJ, Cen O, Sur S, Alam R | title = Unc119, a novel activator of Lck/Fyn, is essential for T cell activation | journal = J. Exp. Med. | volume = 199 | issue = 3 | pages = 369–79 | date = Feb 2004 | pmid = 14757743 | pmc = 2211793 | doi = 10.1084/jem.20030589 }}

References

External links

{{MeshName|CD247+protein,+human}}
{{UCSC gene info|CD247}}
{{PDBe-KB2|P20963|Human T-cell surface glycoprotein CD3 zeta chain (CD247)}}

Category:Clusters of differentiation