TAAR8
{{Short description|Protein and coding gene in humans}}
{{Infobox_gene}}
Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | display-authors = 6 | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 | date = September 2001 | pmid = 11574155 | doi = 10.1016/S0378-1119(01)00651-5 }}{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 | date = March 2005 | pmid = 15718104 | doi = 10.1016/j.ygeno.2004.11.010 }}{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551}} In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o-coupled.{{cite journal | vauthors = Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H | display-authors = 6 | title = Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile | journal = International Journal of Molecular Sciences | volume = 15 | issue = 11 | pages = 20638–55 | date = November 2014 | pmid = 25391046 | pmc = 4264187 | doi = 10.3390/ijms151120638 | doi-access = free }}
In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.{{cite journal | vauthors = Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A | title = Identifying human diamine sensors for death related putrescine and cadaverine molecules | journal = PLOS Computational Biology | volume = 14 | issue = 1 | pages = e1005945 | date = January 2018 | pmid = 29324768 | pmc = 5783396 | doi = 10.1371/journal.pcbi.1005945 | bibcode = 2018PLSCB..14E5945I | doi-access = free }}
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM
See also
References
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Further reading
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- {{cite journal | vauthors = Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C | display-authors = 6 | title = Trace amines: identification of a family of mammalian G protein-coupled receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 16 | pages = 8966–71 | date = July 2001 | pmid = 11459929 | pmc = 55357 | doi = 10.1073/pnas.151105198 | bibcode = 2001PNAS...98.8966B | doi-access = free }}
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{{NLM content}}
{{TAAR ligands}}
{{G protein-coupled receptors}}
Category:G protein-coupled receptors
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