TACC3
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.{{cite journal | vauthors = Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP | title = The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival | journal = J Biol Chem | volume = 282 | issue = 40 | pages = 29273–83 |date=Oct 2007 | pmid = 17675670 | doi = 10.1074/jbc.M704151200 | doi-access = free }}{{cite web | title = Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10460}}
The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.
References
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Further reading
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- {{cite journal |vauthors=Lappin TR, Mullan RN, Stewart JP, etal |title=AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains |journal=Leuk. Lymphoma |volume=43 |issue= 7 |pages= 1455–9 |year= 2003 |pmid= 12389629 |doi=10.1080/1042819022386644 |s2cid=2098614 }}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors=Still IH, Vince P, Cowell JK |title=The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines |journal=Genomics |volume=58 |issue= 2 |pages= 165–70 |year= 1999 |pmid= 10366448 |doi= 10.1006/geno.1999.5829 }}
- {{cite journal |vauthors=Gergely F, Karlsson C, Still I, etal |title=The TACC domain identifies a family of centrosomal proteins that can interact with microtubules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14352–7 |year= 2001 |pmid= 11121038 |doi= 10.1073/pnas.97.26.14352 | pmc=18922 |doi-access=free }}
- {{cite journal |vauthors=McKeveney PJ, Hodges VM, Mullan RN, etal |title=Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells |journal=Br. J. Haematol. |volume=112 |issue= 4 |pages= 1016–24 |year= 2001 |pmid= 11298601 |doi=10.1046/j.1365-2141.2001.02644.x |s2cid=27869385 |doi-access= }}
- {{cite journal |vauthors=Piekorz RP, Hoffmeyer A, Duntsch CD, etal |title=The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis |journal=EMBO J. |volume=21 |issue= 4 |pages= 653–64 |year= 2002 |pmid= 11847113 |doi=10.1093/emboj/21.4.653 | pmc=125348 }}
- {{cite journal |vauthors=Steadman BT, Schmidt PH, Shanks RA, etal |title=Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30165–76 |year= 2002 |pmid= 12015314 |doi= 10.1074/jbc.M201914200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Sadek CM, Pelto-Huikko M, Tujague M, etal |title=TACC3 expression is tightly regulated during early differentiation |journal=Gene Expr. Patterns |volume=3 |issue= 2 |pages= 203–11 |year= 2004 |pmid= 12711550 |doi=10.1016/S1567-133X(02)00066-2 }}
- {{cite journal | vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 |citeseerx=10.1.1.539.8359 }}
- {{cite journal |vauthors=Gangisetty O, Lauffart B, Sondarva GV, etal |title=The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases |journal=Oncogene |volume=23 |issue= 14 |pages= 2559–63 |year= 2004 |pmid= 14767476 |doi= 10.1038/sj.onc.1207424 |doi-access= |s2cid=22590391 }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
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