TAP2

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (TAP1). The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia,{{cite journal | vauthors = Yu H | title = Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population. | journal = Journal of Psychiatric Research | year = 2014 | volume = 50 | pages = 73–8 | doi = 10.1016/j.jpsychires.2013.11.014 | pmid = 24365204 }} and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.{{cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891}}

• ATP-binding cassette transporter

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• {{cite journal | vauthors = Townsend A, Trowsdale J | title = The transporters associated with antigen presentation | journal = Semin. Cell Biol. | volume = 4 | issue = 1 | pages = 53–61 | year = 1993 | pmid = 8453065 | doi = 10.1006/scel.1993.1007 }}
• {{cite journal | vauthors = Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J | title = DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing | journal = J. Mol. Biol. | volume = 228 | issue = 2 | pages = 433–41 | year = 1992 | pmid = 1453454 | doi = 10.1016/0022-2836(92)90832-5 }}
• {{cite journal | vauthors = Kelly A, Powis SH, Kerr LA, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A | title = Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex | journal = Nature | volume = 355 | issue = 6361 | pages = 641–4 | year = 1992 | pmid = 1538751 | doi = 10.1038/355641a0 | bibcode = 1992Natur.355..641K | s2cid = 32569414 | doi-access = free }}
• {{cite journal | vauthors = Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T | title = Allelic variants of the human putative peptide transporter involved in antigen processing | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 9 | pages = 3932–6 | year = 1992 | pmid = 1570316 | pmc = 525605 | doi = 10.1073/pnas.89.9.3932 | bibcode = 1992PNAS...89.3932C | doi-access = free }}
• {{cite journal | vauthors = Powis SH, Mockridge I, Kelly A, Kerr LA, Glynne R, Gileadi U, Beck S, Trowsdale J | title = Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 4 | pages = 1463–7 | year = 1992 | pmid = 1741401 | pmc = 48471 | doi = 10.1073/pnas.89.4.1463 | bibcode = 1992PNAS...89.1463P | doi-access = free }}
• {{cite journal | vauthors = Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A | title = Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters | journal = Nature | volume = 348 | issue = 6303 | pages = 741–4 | year = 1991 | pmid = 2259383 | doi = 10.1038/348741a0 | s2cid = 4279033 }}
• {{cite journal | vauthors = de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis SH, Donato L, Bausinger H, Laforet M | title = Homozygous human TAP peptide transporter mutation in HLA class I deficiency | journal = Science | volume = 265 | issue = 5169 | pages = 237–41 | year = 1994 | pmid = 7517574 | doi = 10.1126/science.7517574 | bibcode = 1994Sci...265..237D }}
• {{cite journal | vauthors = Cano P, Baxter-Lowe LA | title = Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain | journal = Tissue Antigens | volume = 45 | issue = 2 | pages = 139–42 | year = 1995 | pmid = 7792761 | doi = 10.1111/j.1399-0039.1995.tb02431.x }}
• {{cite journal | vauthors = Roby KF, Fei K, Yang Y, Hunt JS | title = Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines | journal = Immunology | volume = 83 | issue = 3 | pages = 444–8 | year = 1995 | pmid = 7835969 | pmc = 1415039 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Singal DP, Ye M, Qiu X, D'Souza M | title = Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis | journal = Clin. Exp. Rheumatol. | volume = 12 | issue = 1 | pages = 29–33 | year = 1994 | pmid = 8162639 }}
• {{cite journal | vauthors = Powis SH, Tonks S, Mockridge I, Kelly AP, Bodmer JG, Trowsdale J | title = Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 | journal = Immunogenetics | volume = 37 | issue = 5 | pages = 373–80 | year = 1993 | pmid = 8428770 | doi = 10.1007/BF00216802 | s2cid = 35123181 }}
• {{cite journal | vauthors = Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J | title = The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing | journal = Eur. J. Immunol. | volume = 23 | issue = 4 | pages = 860–6 | year = 1993 | pmid = 8458375 | doi = 10.1002/eji.1830230414 | s2cid = 44733094 }}
• {{cite journal | vauthors = Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J | title = Evolutionary dynamics of non-coding sequences within the class II region of the human MHC | journal = J. Mol. Biol. | volume = 255 | issue = 1 | pages = 1–13 | year = 1996 | pmid = 8568858 | doi = 10.1006/jmbi.1996.0001 }}
• {{cite journal | vauthors = Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R | title = Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 | journal = EMBO J. | volume = 15 | issue = 13 | pages = 3247–55 | year = 1996 | pmid = 8670825 | pmc = 451885 | doi = 10.1002/j.1460-2075.1996.tb00689.x}}
• {{cite journal | vauthors = Pattanakitsakul S, Takeuchi F, Nabeta H, Nakano K, Kuwata S, Yanagisawa M, Shibata Y, Ito K | title = A novel TAP 2 gene RFLP observed in a Japanese | journal = Tissue Antigens | volume = 47 | issue = 4 | pages = 353–5 | year = 1996 | pmid = 8773329 | doi = 10.1111/j.1399-0039.1996.tb02567.x }}
• {{cite journal | vauthors = Lewis JW, Neisig A, Neefjes J, Elliott T | title = Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP | journal = Curr. Biol. | volume = 6 | issue = 7 | pages = 873–83 | year = 1997 | pmid = 8805302 | doi = 10.1016/S0960-9822(02)00611-5 | doi-access = free }}

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• {{MeshName|TAP2+protein,+human}}

{{NLM content}}

{{ABC transporters}}

Category:ATP-binding cassette transporters

{{membrane-protein-stub}}