TARBP1

{{short description|Protein-coding gene in the species Homo sapiens}}

Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.{{cite journal | vauthors = Wu F, Garcia J, Sigman D, Gaynor R |author4-link=Richard Gaynor| title = tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185 | journal = Genes Dev | volume = 5 | issue = 11 | pages = 2128–40 |date=Dec 1991 | pmid = 1936997 | doi =10.1101/gad.5.11.2128 | doi-access = free }}{{cite web | title = Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6894}}

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.

References

{{cite journal | vauthors=Sheline CT, Milocco LH, Jones KA |title=Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin |journal=Genes Dev. |volume=5 |issue= 12B |pages= 2508–20 |year= 1992 |pmid= 1752441 |doi=10.1101/gad.5.12b.2508 |doi-access=free }}
{{cite journal | vauthors=Wu-Baer F, Sigman D, Gaynor RB |author3-link=Richard Gaynor |title=Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 16 |pages= 7153–7 |year= 1995 |pmid= 7638159 |doi=10.1073/pnas.92.16.7153 | pmc=41297 |bibcode=1995PNAS...92.7153W |doi-access=free }}
{{cite journal | vauthors=Wu-Baer F, Lane WS, Gaynor RB |title=Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4201–8 |year= 1996 |pmid= 8626763 |doi=10.1074/jbc.271.8.4201 |doi-access=free }}
{{cite journal | vauthors=Wu-Baer F, Lane WS, Gaynor RB |title=The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA |journal=EMBO J. |volume=14 |issue= 23 |pages= 5995–6009 |year= 1996 |doi=10.1002/j.1460-2075.1995.tb00288.x |pmid= 8846792 | pmc=394719 }}
{{cite journal | vauthors=Yedavalli VS, Benkirane M, Jeang KT |title=Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1 |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6404–10 |year= 2003 |pmid= 12458222 |doi= 10.1074/jbc.M209162200 |doi-access= free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}

TARBP1

References

Further reading