TAS2R7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.{{cite journal | vauthors = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | date = Apr 2000 | pmid = 10761934 | doi = 10.1016/S0092-8674(00)80705-9 | s2cid = 14604586 | doi-access = free }}{{cite journal | vauthors = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | date = Apr 2000 | pmid = 10766242 | doi = 10.1038/35007072 | bibcode = 2000Natur.404..601M | s2cid = 4336913 }}{{cite web | title = Entrez Gene: TAS2R7 taste receptor, type 2, member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50837}}
Function
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
See also
References
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Further reading
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- {{cite journal | author = Kinnamon SC | title = A plethora of taste receptors. | journal = Neuron | volume = 25 | issue = 3 | pages = 507–10 | year = 2000 | pmid = 10774719 | doi = 10.1016/S0896-6273(00)81054-5 | doi-access = free }}
- {{cite journal | author = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction. | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 1–4 | year = 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 | doi-access = free }}
- {{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste. | journal = Curr. Opin. Neurobiol. | volume = 12 | issue = 4 | pages = 366–71 | year = 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 | s2cid = 37807140 }}
- {{cite journal | vauthors = Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ | title = T2Rs function as bitter taste receptors. | journal = Cell | volume = 100 | issue = 6 | pages = 703–11 | year = 2000 | pmid = 10761935 | doi = 10.1016/S0092-8674(00)80706-0 | s2cid = 7293493 | doi-access = free }}
- {{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | year = 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0 | s2cid = 718601 | doi-access = free }}
- {{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes. | journal = Mol. Biol. Evol. | volume = 22 | issue = 3 | pages = 432–6 | year = 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 | doi-access = free }}
- {{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | year = 2006 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}
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{{NLM content}}
{{G protein-coupled receptors|g3}}
Category:Human taste receptors
{{transmembranereceptor-stub}}