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TCEA1

{{short description|Human protein-coding gene}}

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Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.{{cite journal | vauthors = DiMarco SP, Glover TW, Miller DE, Reines D, Warren ST | title = Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3 | journal = Genomics | volume = 36 | issue = 1 | pages = 185–8 | date = August 1996 | pmid = 8812434 | doi = 10.1006/geno.1996.0443 }}{{cite journal | vauthors = Park H, Baek K, Jeon C, Agarwal K, Yoo O | title = Characterization of the gene encoding the human transcriptional elongation factor TFIIS | journal = Gene | volume = 139 | issue = 2 | pages = 263–7 | date = February 1994 | pmid = 8112616 | doi = 10.1016/0378-1119(94)90767-6 }}{{cite web | title = Entrez Gene: TCEA1 transcription elongation factor A (SII), 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6917}}

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex.{{cite journal | vauthors = Kim B, Nesvizhskii AI, Rani PG, Hahn S, Aebersold R, Ranish JA | title = The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 41 | pages = 16068–73 | date = October 2007 | pmid = 17913884 | doi = 10.1073/pnas.0704573104 | doi-access = free | pmc = 2042163 | bibcode = 2007PNAS..10416068K }} A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.{{cite journal |last1=Robinson |first1=Nicholas P. |last2=Fouqueau |first2=Thomas |last3=Blombach |first3=Fabian |last4=Cackett |first4=Gwenny |last5=Carty |first5=Alice E. |last6=Matelska |first6=Dorota M. |last7=Ofer |first7=Sapir |last8=Pilotto |first8=Simona |last9=Phung |first9=Duy Khanh |last10=Werner |first10=Finn |title=The cutting edge of archaeal transcription |journal=Emerging Topics in Life Sciences |date=14 December 2018 |volume=2 |issue=4 |pages=517–533 |doi=10.1042/ETLS20180014|pmid=33525828 |pmc=7289017 |doi-access=free }}

Interactions

TCEA1 has been shown to interact with GTF2H1{{cite journal | vauthors = Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J | display-authors = 6 | title = FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27593–601 | date = October 1998 | pmid = 9765293 | doi = 10.1074/jbc.273.42.27593 | doi-access = free }}{{cite journal | vauthors = Pan G, Aso T, Greenblatt J | title = Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators | journal = The Journal of Biological Chemistry | volume = 272 | issue = 39 | pages = 24563–71 | date = September 1997 | pmid = 9305922 | doi = 10.1074/jbc.272.39.24563 | doi-access = free }} and POLR2A.{{cite journal | vauthors = Kettenberger H, Armache KJ, Cramer P | title = Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage | journal = Cell | volume = 114 | issue = 3 | pages = 347–57 | date = August 2003 | pmid = 12914699 | doi = 10.1016/S0092-8674(03)00598-1 | hdl = 11858/00-001M-0000-0015-8647-8 | s2cid = 17184533 | hdl-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Chen HC, England L, Kane CM | title = Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II | journal = Gene | volume = 116 | issue = 2 | pages = 253–8 | date = July 1992 | pmid = 1378807 | doi = 10.1016/0378-1119(92)90522-Q }}
  • {{cite journal | vauthors = Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG | title = HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors | journal = Genes & Development | volume = 6 | issue = 4 | pages = 655–66 | date = April 1992 | pmid = 1559613 | doi = 10.1101/gad.6.4.655 | doi-access = free }}
  • {{cite journal | vauthors = Yoo OJ, Yoon HS, Baek KH, Jeon CJ, Miyamoto K, Ueno A, Agarwal K | title = Cloning, expression and characterization of the human transcription elongation factor, TFIIS | journal = Nucleic Acids Research | volume = 19 | issue = 5 | pages = 1073–9 | date = March 1991 | pmid = 1708494 | pmc = 333783 | doi = 10.1093/nar/19.5.1073 }}
  • {{cite journal | vauthors = Reines D, Chamberlin MJ, Kane CM | title = Transcription elongation factor SII (TFIIS) enables RNA polymerase II to elongate through a block to transcription in a human gene in vitro | journal = The Journal of Biological Chemistry | volume = 264 | issue = 18 | pages = 10799–809 | date = June 1989 | doi = 10.1016/S0021-9258(18)81692-1 | pmid = 2471707 | doi-access = free }}
  • {{cite journal | vauthors = Qian X, Jeon C, Yoon H, Agarwal K, Weiss MA | title = Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS | journal = Nature | volume = 365 | issue = 6443 | pages = 277–9 | date = September 1993 | pmid = 7626141 | doi = 10.1038/365277a0 | bibcode = 1993Natur.365..277Q | hdl = 10356/94482 | s2cid = 4367997 | hdl-access = free }}
  • {{cite journal | vauthors = Yeh CH, Shatkin AJ | title = A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII | journal = Gene | volume = 143 | issue = 2 | pages = 285–7 | date = June 1994 | pmid = 8206389 | doi = 10.1016/0378-1119(94)90112-0 }}
  • {{cite journal | vauthors = Umehara T, Kida S, Yamamoto T, Horikoshi M | title = Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II | journal = Gene | volume = 167 | issue = 1–2 | pages = 297–302 | date = December 1995 | pmid = 8566795 | doi = 10.1016/0378-1119(95)00634-6 }}
  • {{cite journal | vauthors = Powell W, Bartholomew B, Reines D | title = Elongation factor SII contacts the 3'-end of RNA in the RNA polymerase II elongation complex | journal = The Journal of Biological Chemistry | volume = 271 | issue = 37 | pages = 22301–4 | date = September 1996 | pmid = 8798387 | pmc = 3371613 | doi = 10.1074/jbc.271.37.22301 | doi-access = free }}
  • {{cite journal | vauthors = Pan G, Aso T, Greenblatt J | title = Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators | journal = The Journal of Biological Chemistry | volume = 272 | issue = 39 | pages = 24563–71 | date = September 1997 | pmid = 9305922 | doi = 10.1074/jbc.272.39.24563 | doi-access = free }}
  • {{cite journal | vauthors = Li XY, Green MR | title = The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor | journal = Genes & Development | volume = 12 | issue = 19 | pages = 2992–6 | date = October 1998 | pmid = 9765201 | pmc = 317190 | doi = 10.1101/gad.12.19.2992 }}
  • {{cite journal | vauthors = Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J | display-authors = 6 | title = FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27593–601 | date = October 1998 | pmid = 9765293 | doi = 10.1074/jbc.273.42.27593 | doi-access = free }}
  • {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | display-authors = 6 | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = October 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
  • {{cite journal | vauthors = Saso K, Ito T, Natori S, Sekimizu K | title = Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II | journal = Journal of Biochemistry | volume = 133 | issue = 4 | pages = 493–500 | date = April 2003 | pmid = 12761297 | doi = 10.1093/jb/mvg065 }}
  • {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | display-authors = 6 | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 35–50 | date = August 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }}
  • {{cite journal | vauthors = Kettenberger H, Armache KJ, Cramer P | title = Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage | journal = Cell | volume = 114 | issue = 3 | pages = 347–57 | date = August 2003 | pmid = 12914699 | doi = 10.1016/S0092-8674(03)00598-1 | hdl = 11858/00-001M-0000-0015-8647-8 | s2cid = 17184533 | hdl-access = free }}
  • {{cite journal | vauthors = Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T | title = Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain | journal = Biochemical and Biophysical Research Communications | volume = 309 | issue = 1 | pages = 189–95 | date = September 2003 | pmid = 12943681 | doi = 10.1016/S0006-291X(03)01556-0 }}
  • {{cite journal | vauthors = Zhang C, Yan H, Burton ZF | title = Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50101–11 | date = December 2003 | pmid = 14506279 | doi = 10.1074/jbc.M307590200 | doi-access = free }}

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