TCF7

{{For|the TCF1 gene|HNF1A}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.{{cite web | title = Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6932}}

References

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Further reading

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  • {{cite journal |vauthors=van de Wetering M, Oosterwegel M, Holstege F, etal |title=The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8530–6 |year= 1992 |doi=10.1016/S0021-9258(18)42476-3 |pmid= 1569101 |doi-access=free }}
  • {{cite journal | vauthors=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123–32 |year= 1991 |pmid= 1989880 |doi= 10.1002/j.1460-2075.1991.tb07928.x| pmc=452620 }}
  • {{cite journal |vauthors=Castrop J, van Wichen D, Koomans-Bitter M, etal |title=The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. |journal=Blood |volume=86 |issue= 8 |pages= 3050–9 |year= 1995 |pmid= 7579399 |doi= 10.1182/blood.V86.8.3050.3050|doi-access=free |hdl=20.500.11755/05a0e0d7-f80c-4035-a8da-056c8b5b7883 |hdl-access=free }}
  • {{cite journal | vauthors=Mayer K, Wolff E, Clevers H, Ballhausen WG |title=The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. |journal=Biochim. Biophys. Acta |volume=1263 |issue= 2 |pages= 169–72 |year= 1995 |pmid= 7640309 |doi= 10.1016/0167-4781(95)00108-s}}
  • {{cite journal | vauthors=Van de Wetering M, Castrop J, Korinek V, Clevers H |title=Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 745–52 |year= 1996 |pmid= 8622675 |doi= 10.1128/mcb.16.3.745| pmc=231054 }}
  • {{cite journal |vauthors=Korinek V, Barker N, Willert K, etal |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248–56 |year= 1998 |pmid= 9488439 |doi= 10.1128/MCB.18.3.1248| pmc=108837 }}
  • {{cite journal |vauthors=Roose J, Molenaar M, Peterson J, etal |title=The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. |journal=Nature |volume=395 |issue= 6702 |pages= 608–12 |year= 1998 |pmid= 9783587 |doi= 10.1038/26989 |bibcode=1998Natur.395..608R |s2cid=4347003 }}
  • {{cite journal |vauthors=Roose J, Huls G, van Beest M, etal |title=Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. |journal=Science |volume=285 |issue= 5435 |pages= 1923–6 |year= 1999 |pmid= 10489374 |doi=10.1126/science.285.5435.1923 }}
  • {{cite journal | vauthors=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=10.1093/nar/29.7.1410 | pmc=31284 }}
  • {{cite journal |vauthors=Batlle E, Henderson JT, Beghtel H, etal |title=Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. |journal=Cell |volume=111 |issue= 2 |pages= 251–63 |year= 2002 |pmid= 12408869 |doi=10.1016/S0092-8674(02)01015-2 |s2cid=10103038 |doi-access=free |hdl=20.500.11755/049536a5-2cae-41f6-a443-9ac675ffc736 |hdl-access=free }}
  • {{cite journal |vauthors=Noble JA, White AM, Lazzeroni LC, etal |title=A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. |journal=Diabetes |volume=52 |issue= 6 |pages= 1579–82 |year= 2003 |pmid= 12765974 |doi=10.2337/diabetes.52.6.1579 |doi-access=free }}
  • {{cite journal |vauthors=Ioannidis V, Kunz B, Tanamachi DM, etal |title=Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 769–75 |year= 2003 |pmid= 12847244 |doi= 10.4049/jimmunol.171.2.769|doi-access=free }}
  • {{cite journal |vauthors=Smit L, Baas A, Kuipers J, etal |title=Wnt activates the Tak1/Nemo-like kinase pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17232–40 |year= 2004 |pmid= 14960582 |doi= 10.1074/jbc.M307801200 |doi-access= free }}
  • {{cite journal | vauthors=Smith SS, Patterson T, Pauza ME |title=Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes. |journal=J. Immunol. |volume=174 |issue= 7 |pages= 3897–905 |year= 2005 |pmid= 15778344 |doi= 10.4049/jimmunol.174.7.3897|doi-access=free }}
  • {{cite journal |vauthors=Willinger T, Freeman T, Herbert M, etal |title=Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1439–46 |year= 2006 |pmid= 16424171 |doi= 10.4049/jimmunol.176.3.1439|doi-access=free |hdl=20.500.11820/b4e3a221-e38b-4f3a-9dbe-1641533de25a |hdl-access=free }}

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{{PDB Gallery|geneid=6932}}

{{Transcription factors and intracellular receptors|g4}}

{{gene-5-stub}}