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TCL1A

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{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.{{cite journal | vauthors = Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM | title = Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient | journal = Proc Natl Acad Sci U S A | volume = 86 | issue = 2 | pages = 602–6 | date = February 1989 | pmid = 2783489 | pmc = 286520 | doi = 10.1073/pnas.86.2.602 | bibcode = 1989PNAS...86..602R | doi-access = free }}{{cite journal | vauthors = Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G | title = Identification of the TCL1 gene involved in T-cell malignancies | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 26 | pages = 12530–4 | date = February 1995 | pmid = 7809072 | pmc = 45472 | doi = 10.1073/pnas.91.26.12530 | doi-access = free }}{{cite web | title = Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8115}}

Interactions

TCL1A has been shown to interact with AKT1{{cite journal | vauthors = Laine J, Künstle G, Obata T, Noguchi M | title = Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3743–51 | date = February 2002 | pmid = 11707444 | doi = 10.1074/jbc.M107069200 | doi-access = free }}{{cite journal | vauthors = Laine J, Künstle G, Obata T, Sha M, Noguchi M | title = The protooncogene TCL1 is an Akt kinase coactivator | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 395–407 | date = August 2000 | pmid = 10983986 | doi = 10.1016/S1097-2765(00)00039-3 | doi-access = free }}{{cite journal | vauthors = French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA | title = A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6376–82 | date = May 2002 | pmid = 12009899 | doi = 10.1021/bi016068o }} and AKT2.

References

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Further reading

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  • {{cite journal | vauthors = Pekarsky Y, Hallas C, Croce CM | title = The role of TCL1 in human T-cell leukemia | journal = Oncogene | volume = 20 | issue = 40 | pages = 5638–43 | year = 2001 | pmid = 11607815 | doi = 10.1038/sj.onc.1204596 | doi-access = free }}
  • {{cite journal | vauthors = Pekarsky Y, Zanesi N, Aqeilan R, Croce CM | title = Tcl1 as a model for lymphomagenesis | journal = Hematol. Oncol. Clin. North Am. | volume = 18 | issue = 4 | pages = 863–79, ix | year = 2004 | pmid = 15325703 | doi = 10.1016/j.hoc.2004.04.007 }}
  • {{cite journal | vauthors = Noguchi M, Ropars V, Roumestand C, Suizu F | title = Proto-oncogene TCL1: more than just a coactivator for Akt | journal = FASEB J. | volume = 21 | issue = 10 | pages = 2273–84 | year = 2007 | pmid = 17360849 | doi = 10.1096/fj.06-7684com | doi-access = free | s2cid = 16946256 | url = https://zenodo.org/record/895567 }}
  • {{cite journal | vauthors = Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM | title = Characterization and localization of the TCL-1 oncogene product | journal = Cancer Res. | volume = 54 | issue = 24 | pages = 6297–301 | year = 1995 | pmid = 7987816 }}
  • {{cite journal | vauthors = Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H | title = Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology | journal = Structure | volume = 6 | issue = 2 | pages = 147–55 | year = 1998 | pmid = 9519406 | doi = 10.1016/S0969-2126(98)00017-3 | doi-access = free }}
  • {{cite journal | vauthors = Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, Aizawa Y, Ueda R, Seto M | title = Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia | journal = Jpn. J. Cancer Res. | volume = 89 | issue = 7 | pages = 712–8 | year = 1998 | pmid = 9738977 | pmc = 5921886 | doi = 10.1111/j.1349-7006.1998.tb03275.x }}
  • {{cite journal | vauthors = Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM | title = Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 6 | pages = 2949–51 | year = 1999 | pmid = 10077617 | pmc = 15875 | doi = 10.1073/pnas.96.6.2949 | bibcode = 1999PNAS...96.2949P | doi-access = free }}
  • {{cite journal | vauthors = Laine J, Künstle G, Obata T, Sha M, Noguchi M | title = The protooncogene TCL1 is an Akt kinase coactivator | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 395–407 | year = 2000 | pmid = 10983986 | doi = 10.1016/S1097-2765(00)00039-3 | doi-access = free }}
  • {{cite journal | vauthors = Laine J, Künstle G, Obata T, Noguchi M | title = Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3743–51 | year = 2002 | pmid = 11707444 | doi = 10.1074/jbc.M107069200 | doi-access = free }}
  • {{cite journal | vauthors = French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA | title = A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane | journal = Biochemistry | volume = 41 | issue = 20 | pages = 6376–82 | year = 2002 | pmid = 12009899 | doi = 10.1021/bi016068o }}
  • {{cite journal | vauthors = Fears S, Chakrabarti SR, Nucifora G, Rowley JD | title = Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression | journal = Cancer Genet. Cytogenet. | volume = 135 | issue = 2 | pages = 110–9 | year = 2002 | pmid = 12127395 | doi = 10.1016/S0165-4608(01)00655-0 }}
  • {{cite journal | vauthors = Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA | title = Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 22 | pages = 14392–7 | year = 2002 | pmid = 12381789 | pmc = 137894 | doi = 10.1073/pnas.212410199 | bibcode = 2002PNAS...9914392H | doi-access = free }}
  • {{cite journal | vauthors = French SW, Malone CS, Shen RR, Renard M, Henson SE, Miner MD, Wall R, Teitell MA | title = Sp1 transactivation of the TCL1 oncogene | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 948–55 | year = 2003 | pmid = 12421830 | doi = 10.1074/jbc.M207166200 | doi-access = free }}
  • {{cite journal | vauthors = Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D | title = TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin | journal = Blood | volume = 101 | issue = 12 | pages = 5007–9 | year = 2004 | pmid = 12576313 | doi = 10.1182/blood-2002-10-3297 | s2cid = 17149852 | doi-access = }}
  • {{cite journal | vauthors = Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L | title = T cell leukemia I oncogene expression depends on the presence of Epstein–Barr virus in the virus- carrying Burkitt lymphoma lines | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4813–8 | year = 2003 | pmid = 12672960 | pmc = 153638 | doi = 10.1073/pnas.0730710100 | bibcode = 2003PNAS..100.4813K | doi-access = free }}

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