TEAD3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.{{cite journal | vauthors = Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I | title = Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis | journal = Genomics | volume = 55 | issue = 1 | pages = 127–9 | date = Jan 1999 | pmid = 9889009 | doi = 10.1006/geno.1998.5628 | hdl = 2268/13836 | hdl-access = free }}{{cite journal | vauthors = Jacquemin P, Martial JA, Davidson I | title = Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer | journal = The Journal of Biological Chemistry | volume = 272 | issue = 20 | pages = 12928–37 | date = May 1997 | pmid = 9148898 | doi = 10.1074/jbc.272.20.12928 | doi-access = free }}{{cite web | title = Entrez Gene: TEAD3 TEA domain family member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005}}
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.{{cite journal | vauthors = Bürglin, TR | title = The TEA domain: a novel, highly conserved DNA-binding motif | journal = Cell | volume = 66 | issue = 1 | pages = 11–12 | date = Jul 1991 | pmid = 2070413 | doi = 10.1016/0092-8674(91)90132-I | s2cid = 2819591 }} Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.{{cite journal | vauthors = Mann CJ, Osborn DP, Hughes SM | title = Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord | journal = Gene Expression Patterns | volume = 7 | issue = 8 | pages = 827–36 | date = Oct 2007 | pmid = 17916448 | pmc = 3360971 | doi = 10.1016/j.modgep.2007.08.001 }} Translation of this protein is initiated at a non-AUG (AUA) start codon.
References
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Further reading
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- {{cite journal | vauthors = Jiang SW, Wu K, Eberhardt NL | title = Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer | journal = Molecular Endocrinology | volume = 13 | issue = 6 | pages = 879–89 | date = Jun 1999 | pmid = 10379887 | doi = 10.1210/mend.13.6.0288 | doi-access = free }}
- {{cite journal | vauthors = Vaudin P, Delanoue R, Davidson I, Silber J, Zider A | title = TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation | journal = Development | volume = 126 | issue = 21 | pages = 4807–16 | date = Nov 1999 | doi = 10.1242/dev.126.21.4807 | pmid = 10518497 }}
- {{cite journal | vauthors = Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML | title = TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm | journal = Genes & Development | volume = 15 | issue = 10 | pages = 1229–41 | date = May 2001 | pmid = 11358867 | pmc = 313800 | doi = 10.1101/gad.888601 }}
- {{cite journal | vauthors = Maeda T, Mazzulli JR, Farrance IK, Stewart AF | title = Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 27 | pages = 24346–52 | date = Jul 2002 | pmid = 11986313 | doi = 10.1074/jbc.M201171200 | doi-access = free }}
- {{cite journal | vauthors = Peng L, Huang Y, Jin F, Jiang SW, Payne AH | title = Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1 | journal = Molecular Endocrinology | volume = 18 | issue = 8 | pages = 2049–60 | date = Aug 2004 | pmid = 15131259 | pmc = 3273420 | doi = 10.1210/me.2004-0028 }}
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External links
- {{MeshName|TEAD3+protein,+human}}
{{PDB Gallery|geneid=7005}}
{{Transcription factors|g3}}
Category:Transcription factors
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