TFDP1

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]

TFDP1 has been shown to interact with:

• E2F1,{{cite journal | vauthors = Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA | title = E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 6 | pages = 2403–7 | date = Mar 1995 | pmid = 7892279 | pmc = 42492 | doi = 10.1073/pnas.92.6.2403| bibcode = 1995PNAS...92.2403S | doi-access = free }}{{cite journal | vauthors = Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K | title = A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer | journal = Oncogene | volume = 17 | issue = 7 | pages = 853–65 | date = Aug 1998 | pmid = 9780002 | doi = 10.1038/sj.onc.1202163 | s2cid = 23588950 | doi-access = }}{{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2536–46 | date = May 1995 | pmid = 7739537 | pmc = 230484 | doi = 10.1128/mcb.15.5.2536}}{{cite journal | vauthors = Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E | title = Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation | journal = Genes Dev. | volume = 7 | issue = 10 | pages = 1850–61 | date = Oct 1993 | pmid = 8405995 | doi = 10.1101/gad.7.10.1850| doi-access = free }}
• E2F5,{{cite journal | vauthors = Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R | title = E2F-5, a new E2F family member that interacts with p130 in vivo | journal = Mol. Cell. Biol. | volume = 15 | issue = 6 | pages = 3082–9 | date = Jun 1995 | pmid = 7760804 | pmc = 230539 | doi = 10.1128/mcb.15.6.3082}} and
• P53.{{cite journal | vauthors = Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB | title = Functional interaction between DP-1 and p53 | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5888–95 | date = Oct 1996 | pmid = 8816502 | pmc = 231590 | doi = 10.1128/mcb.16.10.5888}}

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• {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins. | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2536–46 | year = 1995 | pmid = 7739537 | pmc = 230484 | doi = 10.1128/mcb.15.5.2536}}
• {{cite journal | vauthors = Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R | title = E2F-5, a new E2F family member that interacts with p130 in vivo. | journal = Mol. Cell. Biol. | volume = 15 | issue = 6 | pages = 3082–9 | year = 1995 | pmid = 7760804 | pmc = 230539 | doi = 10.1128/mcb.15.6.3082}}
• {{cite journal | vauthors = Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA | title = E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 6 | pages = 2403–7 | year = 1995 | pmid = 7892279 | pmc = 42492 | doi = 10.1073/pnas.92.6.2403 | bibcode = 1995PNAS...92.2403S | doi-access = free }}
• {{cite journal | vauthors = Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM | title = E2F-4, a new member of the E2F transcription factor family, interacts with p107. | journal = Genes Dev. | volume = 8 | issue = 22 | pages = 2665–79 | year = 1994 | pmid = 7958924 | doi = 10.1101/gad.8.22.2665 | doi-access = free }}
• {{cite journal | vauthors = Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R | title = E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. | journal = Genes Dev. | volume = 8 | issue = 22 | pages = 2680–90 | year = 1994 | pmid = 7958925 | doi = 10.1101/gad.8.22.2680 | doi-access = free }}
• {{cite journal | vauthors = Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB | title = DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. | journal = EMBO J. | volume = 13 | issue = 13 | pages = 3104–14 | year = 1994 | pmid = 8039504 | pmc = 395201 | doi = 10.1002/j.1460-2075.1994.tb06609.x}}
• {{cite journal | vauthors = Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E | title = Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. | journal = Genes Dev. | volume = 7 | issue = 10 | pages = 1850–61 | year = 1993 | pmid = 8405995 | doi = 10.1101/gad.7.10.1850 | doi-access = free }}
• {{cite journal | vauthors = Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM | title = DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 15 | pages = 7594–9 | year = 1996 | pmid = 8755520 | pmc = 38791 | doi = 10.1073/pnas.93.15.7594 | bibcode = 1996PNAS...93.7594R | doi-access = free }}
• {{cite journal | vauthors = Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB | title = Functional interaction between DP-1 and p53. | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5888–95 | year = 1996 | pmid = 8816502 | pmc = 231590 | doi = 10.1128/mcb.16.10.5888}}
• {{cite journal | vauthors = Vidal M, Braun P, Chen E, Boeke JD, Harlow E | title = Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10321–6 | year = 1996 | pmid = 8816798 | pmc = 38382 | doi = 10.1073/pnas.93.19.10321 | bibcode = 1996PNAS...9310321V | doi-access = free }}
• {{cite journal | vauthors = Magae J, Wu CL, Illenye S, Harlow E, Heintz NH | title = Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. | journal = J. Cell Sci. | volume = ( Pt 7) | pages = 1717–26 | year = 1997 | pmid = 8832394 | series = 109 | issue = 7 | doi = 10.1242/jcs.109.7.1717 }}
• {{cite journal | vauthors = Hofmann F, Livingston DM | title = Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. | journal = Genes Dev. | volume = 10 | issue = 7 | pages = 851–61 | year = 1996 | pmid = 8846921 | doi = 10.1101/gad.10.7.851 | doi-access = free }}
• {{cite journal | vauthors = Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA | title = E2F-6, a member of the E2F family that can behave as a transcriptional repressor. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 6 | pages = 2850–5 | year = 1998 | pmid = 9501179 | pmc = 19658 | doi = 10.1073/pnas.95.6.2850 | bibcode = 1998PNAS...95.2850T | doi-access = free }}
• {{cite journal | vauthors = Cartwright P, Müller H, Wagener C, Holm K, Helin K | title = E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. | journal = Oncogene | volume = 17 | issue = 5 | pages = 611–23 | year = 1998 | pmid = 9704927 | doi = 10.1038/sj.onc.1201975 | s2cid = 7688110 | doi-access = }}
• {{cite journal | vauthors = Timchenko NA, Wilde M, Darlington GJ | title = C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. | journal = Mol. Cell. Biol. | volume = 19 | issue = 4 | pages = 2936–45 | year = 1999 | pmid = 10082561 | pmc = 84088 | doi = 10.1128/mcb.19.4.2936}}
• {{cite journal | vauthors = Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG | title = Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors. | journal = Eur. J. Immunol. | volume = 29 | issue = 10 | pages = 3380–9 | year = 1999 | pmid = 10540350 | doi = 10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C | doi-access = free }}
• {{cite journal | vauthors = Sansal I, Dupont E, Toru D, Evrard C, Rouget P | title = NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. | journal = Oncogene | volume = 19 | issue = 43 | pages = 5000–9 | year = 2000 | pmid = 11042687 | doi = 10.1038/sj.onc.1203843 | s2cid = 41370242 | doi-access = }}
• {{cite journal | vauthors = Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV | title = TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2273–85 | year = 2001 | pmid = 11331592 | pmc = 125435 | doi = 10.1093/emboj/20.9.2273 }}

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