Login
Login

THEMIS (protein)

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

THEMIS is a protein encoded by the eponymous THEMIS gene.{{cite journal | vauthors = Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR | display-authors = 6 | title = Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling | journal = Nature Immunology | volume = 10 | issue = 8 | pages = 848–856 | date = August 2009 | pmid = 19597499 | pmc = 2757056 | doi = 10.1038/ni.1766 }}{{cite journal | vauthors = Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE | display-authors = 6 | title = Themis, a T cell-specific protein important for late thymocyte development | journal = Nature Immunology | volume = 10 | issue = 8 | pages = 840–847 | date = August 2009 | pmid = 19597498 | pmc = 2848698 | doi = 10.1038/ni.1768 }}{{cite journal | vauthors = Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH | display-authors = 6 | title = Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection | journal = Nature Immunology | volume = 10 | issue = 8 | pages = 831–839 | date = August 2009 | pmid = 19597497 | pmc = 2908989 | doi = 10.1038/ni.1769 }}

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.{{cite web | title = Entrez Gene: thymocyte selection associated| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387357}} Changes in THEMIS gene expression due to the [https://www.ensembl.org/Homo_sapiens/Variation/Explore?db=core;r=6:127975378-127976378;v=rs138300818;vdb=variation;vf=189226292 rs138300818] variant promote the development of early-onset type 1 diabetes.{{cite journal | vauthors = Sandholm N, Rubio García A, Pekalski ML, Inshaw JR, Cutler AJ, Todd JA | title = Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants | journal = Scientific Reports | volume = 12 | issue = 1 | pages = 14137 | date = August 2022 | pmid = 35986039 | pmc = 9391468 | doi = 10.1038/s41598-022-18296-4 | bibcode = 2022NatSR..1214137S }}

Etymology

THEMIS is an acronym for thymocyte-expressed molecule involved in selection. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.{{cite web | url = http://www.the-scientist.com/2009/11/1/18/1/ | title = Six degrees of science | author = Zielinska E | date = 2009-11-01 | publisher = The Scientist | access-date = 2009-11-03 | archive-date = 2009-11-06 | archive-url = https://web.archive.org/web/20091106075527/http://www.the-scientist.com/2009/11/1/18/1/ | url-status = dead }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | display-authors = 6 | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M | display-authors = 6 | title = Creation of genome-wide protein expression libraries using random activation of gene expression | journal = Nature Biotechnology | volume = 19 | issue = 5 | pages = 440–445 | date = May 2001 | pmid = 11329013 | doi = 10.1038/88107 | s2cid = 25064683 }}
  • {{cite journal | vauthors = Allen PM | title = Themis imposes new law and order on positive selection | journal = Nature Immunology | volume = 10 | issue = 8 | pages = 805–806 | date = August 2009 | pmid = 19621038 | doi = 10.1038/ni0809-805 | s2cid = 205359914 }}

{{refend}}

{{NLM content}}

{{gene-6-stub}}