THOP1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.{{cite journal |vauthors=Torres MP, Prange C, Lennon G | title = Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease | journal = Genomics | volume = 53 | issue = 2 | pages = 239–40 |date=Dec 1998 | pmid = 9790774 | doi = 10.1006/geno.1998.5487 | url = https://zenodo.org/record/1229763 }}{{cite web | title = Entrez Gene: THOP1 thimet oligopeptidase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7064}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Thompson A, Huber G, Malherbe P |title=Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. |journal=Biochem. Biophys. Res. Commun. |volume=213 |issue= 1 |pages= 66–73 |year= 1995 |pmid= 7639763 |doi= 10.1006/bbrc.1995.2099 }}
- {{cite journal |vauthors=Papastoitsis G, Siman R, Scott R, Abraham CR |title=Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. |journal=Biochemistry |volume=33 |issue= 1 |pages= 192–9 |year= 1994 |pmid= 8286339 |doi=10.1021/bi00167a025 }}
- {{cite journal |vauthors=Dando PM, Brown MA, Barrett AJ |title=Human thimet oligopeptidase |journal=Biochem. J. |volume=294 |issue= Pt 2|pages= 451–7 |year= 1993 |pmid= 8373360 |doi= 10.1042/bj2940451| pmc=1134475 }}
- {{cite journal | author=Meckelein B |title=Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus |journal=Genomics |volume=31 |issue= 2 |pages= 246–9 |year= 1997 |pmid= 8824811 |doi= 10.1006/geno.1996.0041 |name-list-style=vanc| author2=de Silva HA | author3=Roses AD | display-authors=3 | last4=Rao | first4=P.Nagesh | last5=Pettenati | first5=Mark J. | last6=Xu | first6=Pu-Ting | last7=Hodge | first7=Rosa | last8=Glucksman | first8=Marc J. | last9=Abraham | first9=Carmela R. | doi-access=free }}
- {{cite journal | author=Crack PJ |title=The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane |journal=Brain Res. |volume=835 |issue= 2 |pages= 113–24 |year= 1999 |pmid= 10415366 |doi=10.1016/S0006-8993(99)01494-8 |name-list-style=vanc| author2=Wu TJ | author3=Cummins PM | display-authors=3 | last4=Ferro | first4=Emer S | last5=Tullai | first5=John W | last6=Glucksman | first6=Marc J | last7=Roberts | first7=James L |s2cid=23769423 }}
- {{cite journal | author=Pineau C |title=Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes |journal=J. Cell Sci. |volume=112 |issue= 20|pages= 3455–62 |year= 2000 |pmid= 10504294 |name-list-style=vanc| author2=McCool S | author3=Glucksman MJ | display-authors=3 | last4=Jégou | first4=B | last5=Pierotti | first5=AR |doi=10.1242/jcs.112.20.3455 }}
- {{cite journal |vauthors=Ferro ES, Tullai JW, Glucksman MJ, Roberts JL |title=Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15) |journal=DNA Cell Biol. |volume=18 |issue= 10 |pages= 781–9 |year= 1999 |pmid= 10541437 |doi= 10.1089/104454999314926 |hdl=11449/37910 |hdl-access=free }}
- {{cite journal | author=Tullai JW |title=The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 36514–22 |year= 2001 |pmid= 10969067 |doi= 10.1074/jbc.M001843200 |name-list-style=vanc| author2=Cummins PM | author3=Pabon A | display-authors=3 | last4=Roberts | first4=JL | last5=Lopingco | first5=MC | last6=Shrimpton | first6=CN | last7=Smith | first7=AI | last8=Martignetti | first8=JA | last9=Ferro | first9=ES | doi-access=free }}
- {{cite journal |vauthors=Molina HM, Carmona AK, Kouyoumdjian M, Borges DR |title=Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase |journal=Life Sci. |volume=67 |issue= 5 |pages= 509–20 |year= 2000 |pmid= 10993116 |doi=10.1016/S0024-3205(00)00650-0 }}
- {{cite journal | author=Saric T |title=Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36474–81 |year= 2001 |pmid= 11479311 |doi= 10.1074/jbc.M105517200 |name-list-style=vanc| author2=Beninga J | author3=Graef CI | display-authors=3 | last4=Akopian | first4=TN | last5=Rock | first5=KL | last6=Goldberg | first6=AL | doi-access=free}}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gioli-Pereira L, Fontenele-Neto JD, Borges DR, Kouyoumdjian M |title=Localization of EP24.15, a major liver kininase |journal=J. Histochem. Cytochem. |volume=51 |issue= 1 |pages= 125–7 |year= 2003 |pmid= 12502762 |doi=10.1177/002215540305100115 |doi-access=free |url=http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3198996 }}
- {{cite journal | author=York IA |title=The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation |journal=Immunity |volume=18 |issue= 3 |pages= 429–40 |year= 2003 |pmid= 12648459 |doi=10.1016/S1074-7613(03)00058-X |name-list-style=vanc| author2=Mo AX | author3=Lemerise K | display-authors=3 | last4=Zeng | first4=Wanyong | last5=Shen | first5=Yuelei | last6=Abraham | first6=Carmela R. | last7=Saric | first7=Tomo | last8=Goldberg | first8=Alfred L. | last9=Rock | first9=Kenneth L. | doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal |vauthors=Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW |title=Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20480–9 |year= 2004 |pmid= 14998993 |doi= 10.1074/jbc.M400795200 |doi-access= free }}
- {{cite journal | author=Grimwood J |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |name-list-style=vanc| author2=Gordon LA | author3=Olsen A | display-authors=3 | last4=Terry | first4=Astrid | last5=Schmutz | first5=Jeremy | last6=Lamerdin | first6=Jane | last7=Hellsten | first7=Uffe | last8=Goodstein | first8=David | last9=Couronne | first9=Olivier |bibcode=2004Natur.428..529G | doi-access=free | url=https://digital.library.unt.edu/ark:/67531/metadc1408307/m2/1/high_res_d/15014060.pdf }}
- {{cite journal |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
- {{cite journal |vauthors=Saric T, Graef CI, Goldberg AL |title=Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46723–32 |year= 2004 |pmid= 15328361 |doi= 10.1074/jbc.M406537200 |doi-access= free }}
- {{cite journal |vauthors=Shivakumar BR, Wang Z, Hammond TG, Harris RC |title=EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor |journal=Cell Biochem. Funct. |volume=23 |issue= 3 |pages= 195–204 |year= 2005 |pmid= 15376229 |doi= 10.1002/cbf.1176 |s2cid=5695331 }}
{{refend}}
{{PDB Gallery|geneid=7064}}
{{gene-19-stub}}