THSD1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.{{cite web | title = Entrez Gene: THSD1 thrombospondin, type I, domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55901| accessdate = }}
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | author=Bork P |title=The modular architecture of a new family of growth regulators related to connective tissue growth factor |journal=FEBS Lett. |volume=327 |issue= 2 |pages= 125–30 |year= 1993 |pmid= 7687569 |doi=10.1016/0014-5793(93)80155-N |doi-access=free }}
- {{cite journal |vauthors=Gruber HE, Ingram JA, Hanley EN |title=Immunolocalization of thrombospondin in the human and sand rat intervertebral disc |journal=Spine |volume=31 |issue= 22 |pages= 2556–61 |year= 2007 |pmid= 17047544 |doi= 10.1097/01.brs.0000241117.31510.e3 |s2cid=43521262 }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal |vauthors=Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE |title=Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48983–92 |year= 2005 |pmid= 15371459 |doi= 10.1074/jbc.M404881200 |doi-access= free }}
- {{cite journal | author=Dunham A |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |name-list-style=vanc| author2=Matthews LH | author3=Burton J | display-authors=3 | last4=Ashurst | first4=J. L. | last5=Howe | first5=K. L. | last6=Ashcroft | first6=K. J. | last7=Beare | first7=D. M. | last8=Burford | first8=D. C. | last9=Hunt | first9=S. E. |bibcode=2004Natur.428..522D }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-style=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{refend}}
{{gene-13-stub}}