TICAM2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.{{cite web | title = Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=353376| accessdate = }}
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]{{cite web | title = Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=353376| accessdate = }}
References
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Further reading
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- {{cite journal |vauthors=Sullivan C, Postlethwait JH, Lage CR, etal |title=Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates |journal=J. Immunol. |volume=178 |issue= 7 |pages= 4517–27 |year= 2007 |pmid= 17372010 |doi= 10.4049/jimmunol.178.7.4517|doi-access=free }}
- {{cite journal |vauthors=Rowe DC, McGettrick AF, Latz E, etal |title=The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 16 |pages= 6299–304 |year= 2006 |pmid= 16603631 |doi= 10.1073/pnas.0510041103 | pmc=1458872 |doi-access=free |bibcode=2006PNAS..103.6299R }}
- {{cite journal |vauthors=Yamamoto M, Sato S, Hemmi H, etal |title=TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway |journal=Nat. Immunol. |volume=4 |issue= 11 |pages= 1144–50 |year= 2003 |pmid= 14556004 |doi= 10.1038/ni986 |s2cid=13016860 }}
- {{cite journal |vauthors=Oshiumi H, Sasai M, Shida K, etal |title=TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49751–62 |year= 2004 |pmid= 14519765 |doi= 10.1074/jbc.M305820200 |doi-access= free}}
- {{cite journal |vauthors=Fitzgerald KA, Rowe DC, Barnes BJ, etal |title=LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF |journal=J. Exp. Med. |volume=198 |issue= 7 |pages= 1043–55 |year= 2003 |pmid= 14517278 |doi= 10.1084/jem.20031023 | pmc=2194210 }}
- {{cite journal |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 |doi-access= |s2cid=38880905 }}
- {{cite journal | vauthors=Bin LH, Xu LG, Shu HB |title=TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24526–32 |year= 2003 |pmid= 12721283 |doi= 10.1074/jbc.M303451200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, etal |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876 }}
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External links
- {{PDBe-KB2|Q86XR7|TIR domain-containing adapter molecule 2}}
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