TIMM10
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene.{{cite journal | vauthors = Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL | title = The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins | journal = Genomics | volume = 61 | issue = 3 | pages = 259–67 |date=Feb 2000 | pmid = 10552927 | doi = 10.1006/geno.1999.5966 }}{{cite web | title = Entrez Gene: TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26519}}
TIMM10 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]
References
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Further reading
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- {{cite journal |vauthors=Koehler CM, Jarosch E, Tokatlidis K, etal |title=Import of mitochondrial carriers mediated by essential proteins of the intermembrane space |journal=Science |volume=279 |issue= 5349 |pages= 369–73 |year= 1998 |pmid= 9430585 |doi=10.1126/science.279.5349.369 }}
- {{cite journal |vauthors=Bauer MF, Rothbauer U, Mühlenbein N, etal |title=The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom |journal=FEBS Lett. |volume=464 |issue= 1–2 |pages= 41–7 |year= 2000 |pmid= 10611480 |doi=10.1016/S0014-5793(99)01665-8 |s2cid=27484018 |doi-access=free }}
- {{cite journal |vauthors=Rothbauer U, Hofmann S, Mühlenbein N, etal |title=Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37327–34 |year= 2001 |pmid= 11489896 |doi= 10.1074/jbc.M105313200 |doi-access= free }}
- {{cite journal |vauthors=Vial S, Lu H, Allen S, etal |title=Assembly of Tim9 and Tim10 into a functional chaperone |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36100–8 |year= 2002 |pmid= 12138093 |doi= 10.1074/jbc.M202310200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Allen S, Lu H, Thornton D, Tokatlidis K |title=Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10 |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38505–13 |year= 2003 |pmid= 12882976 |doi= 10.1074/jbc.M306027200 |doi-access= free }}
- {{cite journal | vauthors=Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF |title=Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13540–6 |year= 2004 |pmid= 14726512 |doi= 10.1074/jbc.M312485200 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Webb CT, Gorman MA, Lazarou M, etal |title=Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller |journal=Mol. Cell |volume=21 |issue= 1 |pages= 123–33 |year= 2006 |pmid= 16387659 |doi= 10.1016/j.molcel.2005.11.010 |doi-access= free }}
- {{cite journal |vauthors=Carey KA, Segal D, Klein R, etal |title=Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays |journal=Pathol. Int. |volume=56 |issue= 5 |pages= 246–55 |year= 2006 |pmid= 16669873 |doi= 10.1111/j.1440-1827.2006.01958.x |s2cid=29365940 }}
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