TIMM10B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene.{{cite journal |vauthors=Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL | title = The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins | journal = Genomics | volume = 61 | issue = 3 | pages = 259–67 |date=Feb 2000 | pmid = 10552927 | doi = 10.1006/geno.1999.5966 }}{{cite web | title = Entrez Gene: FXC1 fracture callus 1 homolog (rat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26515}}
FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM]
References
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Further reading
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- {{cite journal | author=Hadjiargyrou M |title=Cloning of a novel cDNA expressed during the early stages of fracture healing |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 3 |pages= 879–84 |year= 1998 |pmid= 9731230 |doi= 10.1006/bbrc.1998.9167 |name-list-style=vanc| author2=Halsey MF | author3=Ahrens W | display-authors=3 | last4=Rightmire | first4=Eric P. | last5=McLeod | first5=Kenneth J. | last6=Rubin | first6=Clinton T. }}
- {{cite journal | author=Bauer MF |title=The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom |journal=FEBS Lett. |volume=464 |issue= 1–2 |pages= 41–7 |year= 2000 |pmid= 10611480 |doi=10.1016/S0014-5793(99)01665-8 |name-list-style=vanc| author2=Rothbauer U | author3=Mühlenbein N | display-authors=3 | last4=Smith | first4=Richard J.H. | last5=Gerbitz | first5=Klaus-Dieter | last6=Neupert | first6=Walter | last7=Brunner | first7=Michael | last8=Hofmann | first8=Sabine |s2cid=27484018 | doi-access=free }}
- {{cite journal | author=Rothbauer U |title=Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37327–34 |year= 2001 |pmid= 11489896 |doi= 10.1074/jbc.M105313200 |name-list-style=vanc| author2=Hofmann S | author3=Mühlenbein N | display-authors=3 | last4=Paschen | first4=SA | last5=Gerbitz | first5=KD | last6=Neupert | first6=W | last7=Brunner | first7=M | last8=Bauer | first8=MF | doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal |vauthors=Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF |title=Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13540–6 |year= 2004 |pmid= 14726512 |doi= 10.1074/jbc.M312485200 |doi-access= free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
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