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TINF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.{{cite journal | vauthors = Kim SH, Kaminker P, Campisi J | title = TIN2, a new regulator of telomere length in human cells | journal = Nature Genetics | volume = 23 | issue = 4 | pages = 405–12 | date = Dec 1999 | pmid = 10581025 | pmc = 4940194| doi = 10.1038/70508 }}{{cite web | title = Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26277}} TINF2 is a component of the shelterin protein complex found at the end of telomeres.{{cite journal | vauthors = Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP | title = TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita | journal = American Journal of Human Genetics | volume = 82 | issue = 2 | pages = 501–9 | date = Feb 2008 | pmid = 18252230 | pmc = 2427222 | doi = 10.1016/j.ajhg.2007.10.004 }}

Interactions

TINF2 has been shown to interact with ACD,{{cite journal | vauthors = Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T | title = POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex | journal = Genes & Development | volume = 18 | issue = 14 | pages = 1649–54 | date = Jul 2004 | pmid = 15231715 | pmc = 478187 | doi = 10.1101/gad.1215404 }}{{cite journal | vauthors = Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z | title = PTOP interacts with POT1 and regulates its localization to telomeres | journal = Nature Cell Biology | volume = 6 | issue = 7 | pages = 673–80 | date = Jul 2004 | pmid = 15181449 | doi = 10.1038/ncb1142 | s2cid = 11543383 }} POT1{{cite journal | vauthors = Loayza D, De Lange T | title = POT1 as a terminal transducer of TRF1 telomere length control | journal = Nature | volume = 423 | issue = 6943 | pages = 1013–8 | date = Jun 2003 | pmid = 12768206 | doi = 10.1038/nature01688 | bibcode = 2003Natur.423.1013L | s2cid = 4370276 }} and TERF1.{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | doi-access = free | hdl = 11858/00-001M-0000-0010-8592-0 | hdl-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Li B, Oestreich S, de Lange T | title = Identification of human Rap1: implications for telomere evolution | journal = Cell | volume = 101 | issue = 5 | pages = 471–83 | date = May 2000 | pmid = 10850490 | doi = 10.1016/S0092-8674(00)80858-2 | doi-access = free }}
  • {{cite journal | vauthors = Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG | title = A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins | journal = European Journal of Human Genetics | volume = 10 | issue = 2 | pages = 107–12 | date = Feb 2002 | pmid = 11938440 | doi = 10.1038/sj.ejhg.5200775 | doi-access = free }}
  • {{cite journal | vauthors = Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N | title = Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers | journal = Anticancer Research | volume = 22 | issue = 6A | pages = 3303–7 | year = 2003 | pmid = 12530079 }}
  • {{cite journal | vauthors = Loayza D, De Lange T | title = POT1 as a terminal transducer of TRF1 telomere length control | journal = Nature | volume = 423 | issue = 6943 | pages = 1013–8 | date = Jun 2003 | pmid = 12768206 | doi = 10.1038/nature01688 | bibcode = 2003Natur.423.1013L | s2cid = 4370276 }}
  • {{cite journal | vauthors = Kim SH, Han S, You YH, Chen DJ, Campisi J | title = The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro | journal = EMBO Reports | volume = 4 | issue = 7 | pages = 685–91 | date = Jul 2003 | pmid = 12835755 | pmc = 1326318 | doi = 10.1038/sj.embor.embor872 }}
  • {{cite journal | vauthors = Loayza D, Parsons H, Donigian J, Hoke K, de Lange T | title = DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 13241–8 | date = Mar 2004 | pmid = 14715659 | doi = 10.1074/jbc.M312309200 | doi-access = free }}
  • {{cite journal | vauthors = Ye JZ, de Lange T | title = TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex | journal = Nature Genetics | volume = 36 | issue = 6 | pages = 618–23 | date = Jun 2004 | pmid = 15133513 | doi = 10.1038/ng1360 | doi-access = free }}
  • {{cite journal | vauthors = Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z | title = PTOP interacts with POT1 and regulates its localization to telomeres | journal = Nature Cell Biology | volume = 6 | issue = 7 | pages = 673–80 | date = Jul 2004 | pmid = 15181449 | doi = 10.1038/ncb1142 | s2cid = 11543383 }}
  • {{cite journal | vauthors = Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T | title = POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex | journal = Genes & Development | volume = 18 | issue = 14 | pages = 1649–54 | date = Jul 2004 | pmid = 15231715 | pmc = 478187 | doi = 10.1101/gad.1215404 }}
  • {{cite journal | vauthors = Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J | title = TIN2 mediates functions of TRF2 at human telomeres | journal = The Journal of Biological Chemistry | volume = 279 | issue = 42 | pages = 43799–804 | date = Oct 2004 | pmid = 15292264 | doi = 10.1074/jbc.M408650200 | doi-access =free }}
  • {{cite journal | vauthors = Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T | title = TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 47264–71 | date = Nov 2004 | pmid = 15316005 | doi = 10.1074/jbc.M409047200 | doi-access = free }}
  • {{cite journal | vauthors = Liu D, O'Connor MS, Qin J, Songyang Z | title = Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 49 | pages = 51338–42 | date = Dec 2004 | pmid = 15383534 | doi = 10.1074/jbc.M409293200 | doi-access = free }}
  • {{cite journal | vauthors = Oh BK, Kim YJ, Park C, Park YN | title = Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis | journal = The American Journal of Pathology | volume = 166 | issue = 1 | pages = 73–80 | date = Jan 2005 | pmid = 15632001 | pmc = 1602303 | doi = 10.1016/S0002-9440(10)62233-X }}
  • {{cite journal | vauthors = Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA | title = Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2 | journal = Journal of Cell Science | volume = 118 | issue = Pt 6 | pages = 1321–30 | date = Mar 2005 | pmid = 15741234 | pmc = 2933191 | doi = 10.1242/jcs.01709 }}

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External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=dkc GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita]
  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q9BSI4 PDBe-KB] provides an overview of all the structure information available in the PDB for Human TERF1-interacting nuclear factor 2 (TINF2)

{{Chromosome genetics}}

Category:Telomere-related proteins

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