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TIPIN

{{Short description|Protein-coding gene in the species Homo sapiens}}

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TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.{{cite journal | vauthors = Gotter AL | title = Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association | journal = Journal of Molecular Biology | volume = 331 | issue = 1 | pages = 167–76 | date = Aug 2003 | pmid = 12875843 | doi = 10.1016/S0022-2836(03)00633-8 }}{{cite journal | vauthors = Yoshizawa-Sugata N, Masai H | title = Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint | journal = The Journal of Biological Chemistry | volume = 282 | issue = 4 | pages = 2729–40 | date = Jan 2007 | pmid = 17102137 | doi = 10.1074/jbc.M605596200 | doi-access = free }}{{cite web | title = Entrez Gene: TIPIN TIMELESS interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54962}}

Interactions

TIPIN has been shown to interact with Replication protein A1.{{cite journal | vauthors = Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK | title = The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement | journal = Molecular and Cellular Biology | volume = 27 | issue = 8 | pages = 3131–42 | date = Apr 2007 | pmid = 17296725 | pmc = 1899931 | doi = 10.1128/MCB.02190-06 }}

References

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Further reading

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  • {{cite journal | vauthors = Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK | title = The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement | journal = Molecular and Cellular Biology | volume = 27 | issue = 8 | pages = 3131–42 | date = Apr 2007 | pmid = 17296725 | pmc = 1899931 | doi = 10.1128/MCB.02190-06 }}
  • {{cite journal | vauthors = Gotter AL, Suppa C, Emanuel BS | title = Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors | journal = Journal of Molecular Biology | volume = 366 | issue = 1 | pages = 36–52 | date = Feb 2007 | pmid = 17141802 | doi = 10.1016/j.jmb.2006.10.097 | pmc = 4151250 }}
  • {{cite journal | vauthors = Chou DM, Elledge SJ | title = Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 48 | pages = 18143–7 | date = Nov 2006 | pmid = 17116885 | pmc = 1654129 | doi = 10.1073/pnas.0609251103 | bibcode = 2006PNAS..10318143C | doi-access = free }}
  • {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}

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