TLE2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.{{cite journal |vauthors=Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S | title = Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia | journal = Genomics | volume = 31 | issue = 1 | pages = 58–64 |date=Oct 1996 | pmid = 8808280 | doi = 10.1006/geno.1996.0009 | doi-access = free }}{{cite web | title = Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7089}}

Interactions

TLE2 has been shown to interact with TLE1{{cite journal |last=Grbavec |first=D |author2=Lo R |author3=Liu Y |author4=Stifani S |date=Dec 1998 |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development |journal=Eur. J. Biochem. |volume=258 |issue=2 |pages=339–49 |location = GERMANY| issn = 0014-2956| pmid = 9874198 |doi=10.1046/j.1432-1327.1998.2580339.x |doi-access=free }} and HES1.

References

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Further reading

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  • {{cite journal |vauthors=Stifani S, Blaumueller CM, Redhead NJ, etal |title=Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 119–27 |year= 1993 |pmid= 1303260 |doi= 10.1038/ng1092-119 |s2cid=32142845 }}
  • {{cite journal |vauthors=Miyasaka H, Choudhury BK, Hou EW, Li SS |title=Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. |journal=Eur. J. Biochem. |volume=216 |issue= 1 |pages= 343–52 |year= 1993 |pmid= 8365415 |doi=10.1111/j.1432-1033.1993.tb18151.x |doi-access=free }}
  • {{cite journal |vauthors=Palaparti A, Baratz A, Stifani S |title=The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26604–10 |year= 1997 |pmid= 9334241 |doi=10.1074/jbc.272.42.26604 |doi-access=free }}
  • {{cite journal |vauthors=Grbavec D, Lo R, Liu Y, etal |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. |journal=Biochem. J. |volume=337 |issue= 1|pages= 13–7 |year= 1999 |pmid= 9854018 |doi=10.1042/0264-6021:3370013 | pmc=1219929 }}
  • {{cite journal |vauthors=Grbavec D, Lo R, Liu Y, Stifani S |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 339–49 |year= 1999 |pmid= 9874198 |doi=10.1046/j.1432-1327.1998.2580339.x |doi-access=free }}
  • {{cite journal |vauthors=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125–37 |year= 1999 |pmid= 9887105 |doi=10.1101/gad.13.1.125 | pmc=316372 }}
  • {{cite journal |vauthors=Javed A, Guo B, Hiebert S, etal |title=Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. |journal=J. Cell Sci. |volume=113 |issue= 12|pages= 2221–31 |year= 2000 |doi=10.1242/jcs.113.12.2221 |pmid= 10825294 }}
  • {{cite journal |vauthors=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=10.1093/nar/29.7.1410 | pmc=31284 }}
  • {{cite journal |vauthors=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 |s2cid=39560486 |url= https://digital.csic.es/bitstream/10261/112516/4/jbc.M108417200.full.pdf |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Higa LA, Wu M, Ye T, etal |title=CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. |journal=Nat. Cell Biol. |volume=8 |issue= 11 |pages= 1277–83 |year= 2006 |pmid= 17041588 |doi= 10.1038/ncb1490 |s2cid=22180568 |hdl=10397/34293 |hdl-access=free }}

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