TLE4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.{{cite journal | vauthors = Miyasaka H, Choudhury BK, Hou EW, Li SS | title = Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein | journal = European Journal of Biochemistry | volume = 216 | issue = 1 | pages = 343–52 | date = August 1993 | pmid = 8365415 | doi = 10.1111/j.1432-1033.1993.tb18151.x | doi-access = free }}{{cite web | title = Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7091}}
Interactions
TLE4 has been shown to interact with PAX5.{{cite journal | vauthors = Eberhard D, Jiménez G, Heavey B, Busslinger M | title = Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family | journal = The EMBO Journal | volume = 19 | issue = 10 | pages = 2292–303 | date = May 2000 | pmid = 10811620 | pmc = 384353 | doi = 10.1093/emboj/19.10.2292 }}{{cite journal | vauthors = Milili M, Gauthier L, Veran J, Mattei MG, Schiff C | title = A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes | journal = Immunology | volume = 106 | issue = 4 | pages = 447–55 | date = August 2002 | pmid = 12153506 | pmc = 1782747 | doi = 10.1046/j.1365-2567.2002.01456.x }}
References
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Further reading
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- {{cite journal | vauthors = Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S | title = Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins | journal = Nature Genetics | volume = 2 | issue = 2 | pages = 119–27 | date = October 1992 | pmid = 1303260 | doi = 10.1038/ng1092-119 | s2cid = 32142845 }}
- {{cite journal | vauthors = Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 5 | pages = 337–45 | date = October 1999 | pmid = 10574462 | doi = 10.1093/dnares/6.5.337 | doi-access = free }}
- {{cite journal | vauthors = Eberhard D, Jiménez G, Heavey B, Busslinger M | title = Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family | journal = The EMBO Journal | volume = 19 | issue = 10 | pages = 2292–303 | date = May 2000 | pmid = 10811620 | pmc = 384353 | doi = 10.1093/emboj/19.10.2292 }}
- {{cite journal | vauthors = Milili M, Gauthier L, Veran J, Mattei MG, Schiff C | title = A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes | journal = Immunology | volume = 106 | issue = 4 | pages = 447–55 | date = August 2002 | pmid = 12153506 | pmc = 1782747 | doi = 10.1046/j.1365-2567.2002.01456.x }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
- {{cite journal | vauthors = Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A, Czerny T | title = Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 340–51 | date = January 2007 | pmid = 17060451 | pmc = 1800652 | doi = 10.1128/MCB.00811-06 }}
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{{PDB Gallery|geneid=7091}}
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