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TLL2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.{{cite journal | vauthors = Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS | title = Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19 | journal = Cytogenet Cell Genet | volume = 86 | issue = 1 | pages = 64–5 |date=Oct 1999 | pmid = 10516436 | doi =10.1159/000015412 | s2cid = 42081614 }}

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.{{cite web | title = Entrez Gene: TLL2 tolloid-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7093}}

References

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Further reading

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  • {{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63 |doi-access=free }}
  • {{cite journal |vauthors=Scott IC, Blitz IL, Pappano WN, etal |title=Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. |journal=Dev. Biol. |volume=213 |issue= 2 |pages= 283–300 |year= 1999 |pmid= 10479448 |doi= 10.1006/dbio.1999.9383 |doi-access= free }}
  • {{cite journal |vauthors=Reynolds SD, Zhang D, Puzas JE, etal |title=Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. |journal=Gene |volume=248 |issue= 1–2 |pages= 233–43 |year= 2000 |pmid= 10806368 |doi=10.1016/S0378-1119(00)00114-1 }}
  • {{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal |vauthors=Uzel MI, Scott IC, Babakhanlou-Chase H, etal |title=Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22537–43 |year= 2001 |pmid= 11313359 |doi= 10.1074/jbc.M102352200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

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