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TLX1

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{{Short description|Protein coding gene in Humans}}

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{{Infobox_gene}}

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.{{cite journal | vauthors = Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ | title = Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia | journal = Science | volume = 253 | issue = 5015 | pages = 79–82 | date = Jul 1991 | pmid = 1676542 | doi = 10.1126/science.1676542 | bibcode = 1991Sci...253...79H }}{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | doi = 10.1016/0888-7543(90)90186-X }}{{cite web | title = Entrez Gene: TLX1 T-cell leukemia homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3195}}{{cite journal | vauthors = Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH | title = HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 20 | pages = 8900–4 | date = Oct 1991 | pmc = 52618 | pmid = 1681546 | doi=10.1073/pnas.88.20.8900| doi-access = free | bibcode = 1991PNAS...88.8900K }}{{cite journal | vauthors = Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J | title = A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14) | journal = Blood | volume = 78 | issue = 11 | pages = 2996–3003 | date = Dec 1991 | doi = 10.1182/blood.V78.11.2996.2996 | pmid = 1683261| doi-access = free }}

Interactions

TLX1 has been shown to interact with PPP1CC,{{cite journal | vauthors = Kawabe T, Muslin AJ, Korsmeyer SJ | title = HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint | journal = Nature | volume = 385 | issue = 6615 | pages = 454–8 | date = Jan 1997 | pmid = 9009195 | doi = 10.1038/385454a0 | bibcode = 1997Natur.385..454K | s2cid = 608633 }} PPP2CB and PPP2CA.

References

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Further reading

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  • {{cite journal | vauthors = Allen TD, Zhu YX, Hawley TS, Hawley RG | title = TALE homeoproteins as HOX11-interacting partners in T-cell leukemia | journal = Leukemia & Lymphoma | volume = 39 | issue = 3–4 | pages = 241–56 | date = Oct 2000 | pmid = 11342305 | doi = 10.3109/10428190009065824 | s2cid = 27407074 }}
  • {{cite journal | vauthors = Lu M, Zhang N, Ho AD | title = Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells | journal = Oncogene | volume = 7 | issue = 7 | pages = 1325–30 | date = Jul 1992 | pmid = 1352396 }}
  • {{cite journal | vauthors = Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH | title = HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 20 | pages = 8900–4 | date = Oct 1991 | pmid = 1681546 | pmc = 52618 | doi = 10.1073/pnas.88.20.8900 | doi-access = free | bibcode = 1991PNAS...88.8900K }}
  • {{cite journal | vauthors = Lu M, Gong ZY, Shen WF, Ho AD | title = The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein | journal = The EMBO Journal | volume = 10 | issue = 10 | pages = 2905–10 | date = Oct 1991 | pmid = 1717256 | pmc = 453003 | doi = 10.1002/j.1460-2075.1991.tb07840.x}}
  • {{cite journal | vauthors = Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH | title = The Hox11 gene is essential for cell survival during spleen development | journal = Development | volume = 121 | issue = 9 | pages = 2909–15 | date = Sep 1995 | doi = 10.1242/dev.121.9.2909 | pmid = 7555717 }}
  • {{cite journal | vauthors = Dear TN, Sanchez-Garcia I, Rabbitts TH | title = The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 10 | pages = 4431–5 | date = May 1993 | pmid = 8099440 | pmc = 46525 | doi = 10.1073/pnas.90.10.4431 | doi-access = free | bibcode = 1993PNAS...90.4431D }}
  • {{cite journal | vauthors = Kawabe T, Muslin AJ, Korsmeyer SJ | title = HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint | journal = Nature | volume = 385 | issue = 6615 | pages = 454–8 | date = Jan 1997 | pmid = 9009195 | doi = 10.1038/385454a0 | bibcode = 1997Natur.385..454K | s2cid = 608633 }}
  • {{cite journal | vauthors = Brake RL, Kees UR, Watt PM | title = Multiple negative elements contribute to repression of the HOX11 proto-oncogene | journal = Oncogene | volume = 17 | issue = 14 | pages = 1787–95 | date = Oct 1998 | pmid = 9778044 | doi = 10.1038/sj.onc.1202078 | doi-access = free }}
  • {{cite journal | vauthors = Zhang N, Shen W, Hawley RG, Lu M | title = HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization | journal = Oncogene | volume = 18 | issue = 13 | pages = 2273–9 | date = Apr 1999 | pmid = 10327073 | doi = 10.1038/sj.onc.1202545 | doi-access = free }}
  • {{cite journal | vauthors = Watt PM, Ranford PR, Kees UR | title = Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line | journal = Gene | volume = 234 | issue = 1 | pages = 169–76 | date = Jun 1999 | pmid = 10393251 | doi = 10.1016/S0378-1119(99)00157-2 }}
  • {{cite journal | vauthors = Brake RL, Kees UR, Watt PM | title = A complex containing PBX2 contributes to activation of the proto-oncogene HOX11 | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 1 | pages = 23–34 | date = May 2002 | pmid = 12054735 | doi = 10.1016/S0006-291X(02)00426-6 }}
  • {{cite journal | vauthors = Bodenmiller DM, Baxter CS, Hansen DV, Potter SS | title = Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function | journal = DNA Sequence | volume = 13 | issue = 2 | pages = 77–83 | date = Apr 2002 | pmid = 12180349 | doi = 10.1080/10425170290029981 | s2cid = 38713800 }}
  • {{cite journal | vauthors = Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N | title = Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951 | journal = Blood | volume = 103 | issue = 2 | pages = 442–50 | date = Jan 2004 | pmid = 14504110 | doi = 10.1182/blood-2003-05-1495 | doi-access = free }}
  • {{cite journal | vauthors = Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR | title = A microarray model system identifies potential new target genes of the proto-oncogene HOX11 | journal = Genes, Chromosomes & Cancer | volume = 41 | issue = 4 | pages = 309–20 | date = Dec 2004 | pmid = 15384172 | doi = 10.1002/gcc.20104 | s2cid = 19475690 }}
  • {{cite journal | vauthors = Riz I, Hawley RG | title = G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia | journal = Oncogene | volume = 24 | issue = 36 | pages = 5561–75 | date = Aug 2005 | pmid = 15897879 | pmc = 2408753 | doi = 10.1038/sj.onc.1208727 }}
  • {{cite journal | vauthors = Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK | title = The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells | journal = Leukemia | volume = 20 | issue = 2 | pages = 304–12 | date = Feb 2006 | pmid = 16357834 | doi = 10.1038/sj.leu.2404071 | doi-access = free }}
  • {{cite journal | vauthors = Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR | title = Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice | journal = Oncogene | volume = 25 | issue = 18 | pages = 2575–87 | date = Apr 2006 | pmid = 16407851 | doi = 10.1038/sj.onc.1209285 | doi-access = free }}

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{{Transcription factors and intracellular receptors|g3}}

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