TLX3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.{{cite journal | vauthors = Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M | title = Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 92 | issue = 3–4 | pages = 358 |date=Jul 2001 | pmid = 11435718 | doi =10.1159/000056933 | s2cid = 85323468 | url = http://tud.qucosa.de/id/qucosa%3A27741 }}{{cite journal | vauthors = Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I | title = Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 92 | issue = 3–4 | pages = 354–5 |date=Jul 2001 | pmid = 11435716 | doi =10.1159/000056931 | s2cid = 35224759 }}{{cite web | title = Entrez Gene: TLX3 T-cell leukemia homeobox 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30012}}
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]
References
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Further reading
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- {{cite journal | vauthors=Dear TN, Sanchez-Garcia I, Rabbitts TH |title=The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4431–5 |year= 1993 |pmid= 8099440 |doi=10.1073/pnas.90.10.4431 | pmc=46525 |doi-access=free }}
- {{cite journal |vauthors=Bernard OA, Busson-LeConiat M, Ballerini P, etal |title=A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia |journal=Leukemia |volume=15 |issue= 10 |pages= 1495–504 |year= 2002 |pmid= 11587205 |doi=10.1038/sj.leu.2402249 |s2cid=32493784 |doi-access= }}
- {{cite journal |vauthors=Ballerini P, Blaise A, Busson-Le Coniat M, etal |title=HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis |journal=Blood |volume=100 |issue= 3 |pages= 991–7 |year= 2002 |pmid= 12130513 |doi= 10.1182/blood-2001-11-0093 |s2cid=16589332 |doi-access=free }}
- {{cite journal |vauthors=Matera I, Bachetti T, Cinti R, etal |title=Mutational analysis of the RNX gene in congenital central hypoventilation syndrome |journal=Am. J. Med. Genet. |volume=113 |issue= 2 |pages= 178–82 |year= 2003 |pmid= 12407709 |doi= 10.1002/ajmg.10746 |doi-access= free }}
- {{cite journal |vauthors=Mauvieux L, Leymarie V, Helias C, etal |title=High incidence of Hox11L2 expression in children with T-ALL |journal=Leukemia |volume=16 |issue= 12 |pages= 2417–22 |year= 2003 |pmid= 12454747 |doi= 10.1038/sj.leu.2402709 |s2cid=20611777 |doi-access= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Berger R, Dastugue N, Busson M, etal |title=t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH) |journal=Leukemia |volume=17 |issue= 9 |pages= 1851–7 |year= 2003 |pmid= 12970786 |doi= 10.1038/sj.leu.2403061 |s2cid=24379766 |doi-access= }}
- {{cite journal |vauthors=Cavé H, Suciu S, Preudhomme C, etal |title=Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951 |journal=Blood |volume=103 |issue= 2 |pages= 442–50 |year= 2004 |pmid= 14504110 |doi= 10.1182/blood-2003-05-1495 |doi-access= free }}
- {{cite journal |vauthors=Su XY, Busson M, Della Valle V, etal |title=Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia |journal=Genes Chromosomes Cancer |volume=41 |issue= 3 |pages= 243–9 |year= 2004 |pmid= 15334547 |doi= 10.1002/gcc.20088 |s2cid=19782389 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ballerini P, Busson M, Fasola S, etal |title=NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance |journal=Leukemia |volume=19 |issue= 3 |pages= 468–70 |year= 2005 |pmid= 15674415 |doi= 10.1038/sj.leu.2403654 |s2cid=27045652 |doi-access= }}
- {{cite journal |vauthors=Gottardo NG, Jacoby PA, Sather HN, etal |title=Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols |journal=Leukemia |volume=19 |issue= 9 |pages= 1705–8 |year= 2005 |pmid= 15990867 |doi= 10.1038/sj.leu.2403834 |doi-access= free }}
- {{cite journal |vauthors=Borghini S, Vargiolu M, Di Duca M, etal |title=Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 635–43 |year= 2006 |pmid= 16966433 |doi= 10.1158/1541-7786.MCR-05-0250 |doi-access= free }}
- {{cite journal |vauthors=Nagel S, Scherr M, Kel A, etal |title=Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1 |journal=Cancer Res. |volume=67 |issue= 4 |pages= 1461–71 |year= 2007 |pmid= 17308084 |doi= 10.1158/0008-5472.CAN-06-2615 |doi-access= free }}
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{{Transcription factors and intracellular receptors|g3}}
{{gene-5-stub}}