TM4SF5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.{{cite journal |vauthors=Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM | title = Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer | journal = Gene | volume = 208 | issue = 1 | pages = 25–30 |date=Mar 1998 | pmid = 9479038 | doi =10.1016/S0378-1119(97)00633-1 }}{{cite web | title = Entrez Gene: TM4SF5 transmembrane 4 L six family member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9032}}
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
References
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Further reading
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- {{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |doi=10.1242/jcs.114.23.4143 |pmid= 11739647 }}
- {{cite journal | author=Lee SY |title=Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment |journal=Exp. Cell Res. |volume=312 |issue= 16 |pages= 2983–99 |year= 2006 |pmid= 16828471 |doi= 10.1016/j.yexcr.2006.06.001 |name-list-style=vanc| author2=Kim YT | author3=Lee MS | display-authors=3 | last4=Kim | first4=Yong-Bae | last5=Chung | first5=Eunji | last6=Kim | first6=Semi | last7=Lee | first7=Jung Weon |hdl=10371/3238 | hdl-access=free}}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Kaneko R |title=Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa |journal=Am. J. Gastroenterol. |volume=96 |issue= 12 |pages= 3457–8 |year= 2002 |pmid= 11774983 |name-list-style=vanc| author2=Tsuji N | author3=Kamagata C | display-authors=3 | last4=Endoh | first4=Teruo | last5=Nakamura | first5=Masashi | last6=Kobayashi | first6=Daisuke | last7=Yagihashi | first7=Atsuhito | last8=Watanabe | first8=Naoki |doi=10.1111/j.1572-0241.2001.05355.x |s2cid=31864317 }}
- {{cite journal |vauthors=Wright MD, Ni J, Rudy GB |title=The L6 membrane proteins--a new four-transmembrane superfamily |journal=Protein Sci. |volume=9 |issue= 8 |pages= 1594–600 |year= 2000 |pmid= 10975581 |doi=10.1110/ps.9.8.1594 | pmc=2144728 }}
- {{cite journal | author=Gress TM |title=A pancreatic cancer-specific expression profile |journal=Oncogene |volume=13 |issue= 8 |pages= 1819–30 |year= 1996 |pmid= 8895530 |name-list-style=vanc| author2=Müller-Pillasch F | author3=Geng M | display-authors=3 | last4=Zimmerhackl | first4=F | last5=Zehetner | first5=G | last6=Friess | first6=H | last7=Büchler | first7=M | last8=Adler | first8=G | last9=Lehrach | first9=H }}
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