TMIGD1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene.{{cite web | title = Entrez Gene: Transmembrane and immunoglobulin domain containing 1 | url = https://www.ncbi.nlm.nih.gov/gene/388364 | access-date = 2017-02-20 }} TMIGD1 was discovered by the lab of Giancarlo Marra{{cite journal | vauthors = Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, Bartosova Z, Haider R, Helmchen B, Sabates-Bellver J, Tiwari A, Jiricny J, Marra G | display-authors = 6 | title = Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid) | journal = EMBO Mol Med | volume = 3 | issue = 6 | pages = 334–347 | date = May 2011 | pmid = 3377079 | pmc = 5839393 | doi = 10.1002/emmm.201100141}} and later cloned by Nader Rahimi.{{cite journal | vauthors = Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, Alexandrov I, Henderson J, Rahimi N | display-authors = 6 | title = TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer | journal = Oncotarget | volume = 9 | issue = 11 | pages = 9672–9684 | date = February 2018 | pmid = 29515762 | pmc = 5839393 | doi = 10.18632/oncotarget.23822 }}{{cite journal | vauthors = Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, Schwartz JH, Chitalia V, Rahimi N | display-authors = 6 | title = TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury | journal = The American Journal of Pathology | volume = 185 | issue = 10 | pages = 2757–67 | date = October 2015 | pmid = 26342724 | pmc = 4607757 | doi = 10.1016/j.ajpath.2015.06.006 }} Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine).{{cite journal | vauthors = Thuering E, Ebnet K | display-authors = 1 | title = TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor | journal = Oncogene | volume = 42 | issue = 22 | pages = 1777–1785 | date = April 2023 | pmid = 37087524 | pmc = 10238269 | doi = 10.1038/s41388-023-02696-5}}