TNFAIP3

TNFAIP3 has been shown to interact with TNIP1,{{cite journal |last=Heyninck |first=K |author2=De Valck D |author3=Vanden Berghe W |author4=Van Criekinge W |author5=Contreras R |author6=Fiers W |author7=Haegeman G |author8=Beyaert R |date=June 1999 |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN |journal=J. Cell Biol. |volume=145 |issue=7 |pages=1471–82 |location = UNITED STATES| issn = 0021-9525| pmid = 10385526 |doi=10.1083/jcb.145.7.1471 |pmc=2133159 }} TRAF1,{{cite journal |last=Song |first=H Y |author2=Rothe M |author3=Goeddel D V |date=June 1996 |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue=13 |pages=6721–5 |location = UNITED STATES| issn = 0027-8424| pmid = 8692885 | bibcode =1996PNAS...93.6721S |doi=10.1073/pnas.93.13.6721 |pmc=39093 |doi-access=free }}{{cite journal |last=Heyninck |first=K |author2=Beyaert R |date=January 1999 |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 |journal=FEBS Lett. |volume=442 |issue=2–3 |pages=147–50 |location = NETHERLANDS| issn = 0014-5793| pmid = 9928991 |doi=10.1016/S0014-5793(98)01645-7 |s2cid=19072203 |doi-access=free }} TRAF2, IKBKG,{{cite journal |last=Zhang |first=S Q |author2=Kovalenko A |author3=Cantarella G |author4=Wallach D |date=March 2000 |title=Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation |journal=Immunity |volume=12 |issue=3 |pages=301–11 |location = UNITED STATES| issn = 1074-7613| pmid = 10755617 |doi=10.1016/S1074-7613(00)80183-1 |doi-access=free }} TAX1BP1,{{cite journal |last=De Valck |first=D |author2=Jin D Y |author3=Heyninck K |author4=Van de Craen M |author5=Contreras R |author6=Fiers W |author7=Jeang K T |author8=Beyaert R |date=July 1999 |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue=29 |pages=4182–90 |location = ENGLAND| issn = 0950-9232| pmid = 10435631 |doi = 10.1038/sj.onc.1202787 |doi-access=free }} YWHAB,{{cite journal |last=Vincenz |first=C |author2=Dixit V M |date=August 1996 |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules |journal=J. Biol. Chem. |volume=271 |issue=33 |pages=20029–34 |location = UNITED STATES| issn = 0021-9258| pmid = 8702721 |doi=10.1074/jbc.271.33.20029 |doi-access=free }} YWHAZ,{{cite journal |last=De Valck |first=D |author2=Heyninck K |author3=Van Criekinge W |author4=Vandenabeele P |author5=Fiers W |author6=Beyaert R |date=September 1997 |title=A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue=2 |pages=590–4 |location = UNITED STATES| issn = 0006-291X| pmid = 9299557 |doi = 10.1006/bbrc.1997.7343 }} TRAF6{{cite journal |last=Evans |first=P C |author2=Taylor E R |author3=Coadwell J |author4=Heyninck K |author5=Beyaert R |author6=Kilshaw P J |date=August 2001 |title=Isolation and characterization of two novel A20-like proteins |journal=Biochem. J. |volume=357 |issue=Pt 3 |pages=617–23 |location = England| issn = 0264-6021| pmid = 11463333 |doi=10.1042/0264-6021:3570617 |pmc=1221992 }} and YWHAH.

The TNFAIP3 locus is implicated as a positively associated factor in rheumatoid arthritis (RA). The rs5029937 (T) and the rs6920220 (A) SNPs increase risk of RA by 20 to 40% respectively.{{cite journal |vauthors=Stahl EA, Raychaudhuri S, Remmers EF, etal | title = Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | journal = Nat. Genet. | volume = 42 | issue = 6 | pages = 508–14 |date=June 2010 | pmid = 20453842 | doi = 10.1038/ng.582 | pmc = 4243840 }} A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.

An association with infantile onset intractable inflammatory bowel disease has also been reported.Zheng C, Huang Y, Ye Z, Wang Y, Tang Z, Lu J, Wu J, Zhou Y, Wang L, Huang Z, Yang H, Xue A (2018) Infantile onset intractable inflammatory bowel disease due to novel heterozygous mutations in TNFAIP3 (A20). Inflamm Bowel Dis doi: 10.1093/ibd/izy165

• Haploinsufficiency of A20

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• {{cite journal |vauthors=Dixit VM, Green S, Sarma V, etal |title=Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2973–8 |year= 1990 |doi=10.1016/S0021-9258(19)39896-5 |pmid= 2406243 |doi-access=free }}
• {{cite journal |vauthors=Cooper JT, Stroka DM, Brostjan C, etal |title=A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18068–73 |year= 1996 |pmid= 8663499 |doi=10.1074/jbc.271.30.18068 |doi-access=free }}
• {{cite journal |vauthors=Meng Z, Zhao T, Zhou K, etal |title=A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination |journal=J. Immunol. |volume=198 |issue= 2 |pages= 820–31 |year= 2017 |pmid= 27986908 |doi=10.4049/jimmunol.1600334 |pmc=5220121}}
• {{cite journal |vauthors=Song HY, Rothe M, Goeddel DV |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6721–5 |year= 1996 |pmid= 8692885 |doi=10.1073/pnas.93.13.6721 | pmc=39093 |bibcode=1996PNAS...93.6721S |doi-access=free }}
• {{cite journal |vauthors=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029–34 |year= 1996 |pmid= 8702721 |doi=10.1074/jbc.271.33.20029 |doi-access=free }}
• {{cite journal |vauthors=De Valck D, Heyninck K, Van Criekinge W, etal |title=A20, an inhibitor of cell death, self-associates by its zinc finger domain |journal=FEBS Lett. |volume=384 |issue= 1 |pages= 61–4 |year= 1996 |pmid= 8797804 |doi=10.1016/0014-5793(96)00283-9 |s2cid=29040964 |doi-access= }}
• {{cite journal |vauthors=De Valck D, Heyninck K, Van Criekinge W, etal |title=A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 2 |pages= 590–4 |year= 1997 |pmid= 9299557 |doi= 10.1006/bbrc.1997.7343 }}
• {{cite journal |vauthors=Eliopoulos AG, Blake SM, Floettmann JE, etal |title=Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2 |journal=J. Virol. |volume=73 |issue= 2 |pages= 1023–35 |year= 1999 |pmid= 9882303 |doi= 10.1128/JVI.73.2.1023-1035.1999| pmc=103922 }}
• {{cite journal |vauthors=Heyninck K, Beyaert R |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 |journal=FEBS Lett. |volume=442 |issue= 2–3 |pages= 147–50 |year= 1999 |pmid= 9928991 |doi=10.1016/S0014-5793(98)01645-7 |s2cid=19072203 |doi-access=free }}
• {{cite journal |vauthors=Heyninck K, De Valck D, Vanden Berghe W, etal |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471–82 |year= 1999 |pmid= 10385526 |doi=10.1083/jcb.145.7.1471 | pmc=2133159 |hdl=1854/LU-113881 }}
• {{cite journal |vauthors=De Valck D, Jin DY, Heyninck K, etal |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue= 29 |pages= 4182–90 |year= 1999 |pmid= 10435631 |doi= 10.1038/sj.onc.1202787 |doi-access= free }}
• {{cite journal |vauthors=Zhang SQ, Kovalenko A, Cantarella G, Wallach D |title=Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation |journal=Immunity |volume=12 |issue= 3 |pages= 301–11 |year= 2000 |pmid= 10755617 |doi=10.1016/S1074-7613(00)80183-1 |doi-access=free }}
• {{cite journal |vauthors=Lee EG, Boone DL, Chai S, etal |title=Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice |journal=Science |volume=289 |issue= 5488 |pages= 2350–4 |year= 2000 |pmid= 11009421 |doi=10.1126/science.289.5488.2350 |pmc=3582399|bibcode=2000Sci...289.2350L }}
• {{cite journal |vauthors=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=10.1016/S0014-5793(01)02504-2 |s2cid=32414520 |doi-access= }}
• {{cite journal |vauthors=Van Huffel S, Delaei F, Heyninck K, etal |title=Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30216–23 |year= 2001 |pmid= 11390377 |doi= 10.1074/jbc.M100048200 |doi-access= free }}
• {{cite journal |vauthors=Evans PC, Taylor ER, Coadwell J, etal |title=Isolation and characterization of two novel A20-like proteins |journal=Biochem. J. |volume=357 |issue= Pt 3 |pages= 617–23 |year= 2001 |pmid= 11463333 |doi=10.1042/0264-6021:3570617 | pmc=1221992 }}
• {{cite journal |vauthors=Baltathakis I, Alcantara O, Boldt DH |title=Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling |journal=J. Cell. Biochem. |volume=83 |issue= 2 |pages= 281–90 |year= 2001 |pmid= 11573245 |doi=10.1002/jcb.1231 |s2cid=12756967 }}
• {{cite journal |vauthors=Zetoune FS, Murthy AR, Shao Z, etal |title=A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome |journal=Cytokine |volume=15 |issue= 6 |pages= 282–98 |year= 2002 |pmid= 11594795 |doi= 10.1006/cyto.2001.0921 }}
• {{cite journal |vauthors=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734–9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200 |doi-access= free }}
• {{cite journal | vauthors = Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C | title = Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury | journal = Cell Death Discovery | volume = 4 | issue = 60 | date = May 2018 | page = 60 | pmid = 29796309| pmc =5955943 | doi = 10.1038/s41420-018-0056-3}}
• {{cite journal |vauthors=He KL, Ting AT |title=A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6034–45 |year= 2002 |pmid= 12167698 |doi=10.1128/MCB.22.17.6034-6045.2002 | pmc=133997 }}

{{Refend}}

• {{PDBe-KB2|P21580|Tumor necrosis factor alpha-induced protein 3}}