TNF receptor associated factor

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TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.{{cite journal | vauthors = Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T | title = Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling | journal = Exp. Cell Res. | volume = 254 | issue = 1 | pages = 14–24 |date=January 2000 | pmid = 10623461 | doi = 10.1006/excr.1999.4733 }}

Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.

Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.