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TNIP2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.{{cite journal |vauthors=Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R | title = Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 | journal = J Biol Chem | volume = 276 | issue = 32 | pages = 30216–23 |date=Aug 2001 | pmid = 11390377 | doi = 10.1074/jbc.M100048200 | doi-access = free }}{{cite journal |vauthors=Tadros A, Hughes DP, Dunmore BJ, Brindle NP | title = ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 | journal = Blood | volume = 102 | issue = 13 | pages = 4407–9 |date=Dec 2003 | pmid = 12933576 | doi = 10.1182/blood-2003-05-1602 | doi-access = free }}{{cite web | title = Entrez Gene: TNIP2 TNFAIP3 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79155}} TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.{{Cite web|title=TNIP2 (human)|url=https://www.phosphosite.org/proteinAction.action?id=3406302&showAllSites=true|access-date=2020-10-31|website=www.phosphosite.org}}

References

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Further reading

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  • {{cite journal | author=Heyninck K |title=The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471–82 |year= 1999 |pmid= 10385526 |doi=10.1083/jcb.145.7.1471 | pmc=2133159 |name-list-style=vanc| author2=De Valck D | author3=Vanden Berghe W | display-authors=3 | last4=Van Criekinge | first4=W | last5=Contreras | first5=R | last6=Fiers | first6=W | last7=Haegeman | first7=G | last8=Beyaert | first8=R |hdl=1854/LU-113881}}
  • {{cite journal |vauthors=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=10.1016/S0014-5793(01)02504-2 |s2cid=32414520 |doi-access= }}
  • {{cite journal |vauthors=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734–9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200 |doi-access= free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Liu WK, Chien CY, Chou CK, Su JY |title=An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation |journal=J. Biomed. Sci. |volume=10 |issue= 2 |pages= 242–52 |year= 2003 |pmid= 12595760 |doi= 10.1159/000068708 |s2cid=202644741 }}
  • {{cite journal |vauthors=Hughes DP, Marron MB, Brindle NP |title=The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 |journal=Circ. Res. |volume=92 |issue= 6 |pages= 630–6 |year= 2003 |pmid= 12609966 |doi= 10.1161/01.RES.0000063422.38690.DC |doi-access= free |hdl= 2381/866 |hdl-access= free }}
  • {{cite journal |vauthors=Chien CY, Liu WK, Chou CK, Su JY |title=The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation |journal=FEBS Lett. |volume=543 |issue= 1–3 |pages= 55–60 |year= 2003 |pmid= 12753905 |doi=10.1016/S0014-5793(03)00401-0 |s2cid=31400521 |doi-access=free }}
  • {{cite journal | author=Liu WK |title=The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis |journal=Biochem. J. |volume=378 |issue= Pt 3 |pages= 867–76 |year= 2004 |pmid= 14653779 |doi= 10.1042/BJ20031736 | pmc=1224013 |name-list-style=vanc| author2=Yen PF | author3=Chien CY | display-authors=3 | last4=Fann | first4=Ming-Ji | last5=Su | first5=Jin-Yuan | last6=Chou | first6=Chen-Kung }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |name-list-style=vanc| author2=Bauch A | author3=Ruffner H | display-authors=3 | last4=Angrand | first4=Pierre-Olivier | last5=Bergamini | first5=Giovanna | last6=Croughton | first6=Karen | last7=Cruciat | first7=Cristina | last8=Eberhard | first8=Dirk | last9=Gagneur | first9=Julien |s2cid=11683986 }}
  • {{cite journal | author=Lang V |title=ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5235–48 |year= 2004 |pmid= 15169888 |doi= 10.1128/MCB.24.12.5235-5248.2004 | pmc=419892 |name-list-style=vanc| author2=Symons A | author3=Watton SJ | display-authors=3 | last4=Janzen | first4=J. | last5=Soneji | first5=Y. | last6=Beinke | first6=S. | last7=Howell | first7=S. | last8=Ley | first8=S. C. }}
  • {{cite journal |vauthors=Li CC, Chou CK, Wang MH, Tsai TF |title=Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 300–9 |year= 2006 |pmid= 16480954 |doi= 10.1016/j.bbrc.2006.01.114 }}
  • {{cite journal | author=Greenberg H |title=Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 2 |pages= 591–6 |year= 2006 |pmid= 16554025 |doi= 10.1016/j.bbrc.2006.03.015 |name-list-style=vanc| author2=Ye X | author3=Wilson D | display-authors=3 | last4=Htoo | first4=Aung K. | last5=Hendersen | first5=Todd | last6=Liu | first6=Shu Fang }}
  • {{cite journal | author=Liu Y |title=Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells |journal=J. Radiat. Res. |volume=48 |issue= 1 |pages= 13–20 |year= 2007 |pmid= 17038805 |doi=10.1269/jrr.0615 |name-list-style=vanc| author2=Nakahara T | author3=Miyakoshi J | display-authors=3 | last4=Hu | first4=Dong-Liang | last5=Nakane | first5=Akio | last6=Abe | first6=Yoshinao |bibcode=2007JRadR..48...13L | doi-access=free }}

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