TP53RK
{{Short description|Protein-coding gene in humans}}
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TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.{{cite journal | vauthors = Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y | title = Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 44003–11 | date = Nov 2001 | pmid = 11546806 | doi = 10.1074/jbc.M105669200 | doi-access = free }}{{cite journal | vauthors = Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA | title = Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency | journal = FEBS Letters | volume = 549 | issue = 1–3 | pages = 63–6 | date = Aug 2003 | pmid = 12914926 | doi = 10.1016/S0014-5793(03)00770-1 | s2cid = 24581860 | doi-access = }}{{cite web | title = Entrez Gene: TP53RK TP53 regulating kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112858}} This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.
PRPK is part of the KEOPS/EKC complex, which participates in transcription control,{{cite journal | vauthors = Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D | title = Yeast homolog of a cancer-testis antigen defines a new transcription complex | journal = The EMBO Journal | volume = 25 | issue = 15 | pages = 3576–85 | date = Aug 2006 | pmid = 16874308 | pmc = 1538566| doi = 10.1038/sj.emboj.7601235 }} telomere regulation {{cite journal | vauthors = Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D | title = A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator | journal = Cell | volume = 124 | issue = 6 | pages = 1155–68 | date = Mar 2006 | pmid = 16564010 | doi = 10.1016/j.cell.2005.12.044 | s2cid = 13928061 | doi-access = free }} and tRNA modification.{{cite journal | vauthors = Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R | title = The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A | journal = The EMBO Journal | volume = 30 | issue = 5 | pages = 873–81 | date = Mar 2011 | pmid = 21183954 | pmc = 3049205| doi = 10.1038/emboj.2010.343 }}
References
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Further reading
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- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N | title = Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein | journal = Biochemical and Biophysical Research Communications | volume = 303 | issue = 2 | pages = 399–405 | date = Apr 2003 | pmid = 12659830 | doi = 10.1016/S0006-291X(03)00333-4 }}
- {{cite journal | vauthors = Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC |author12-link=Mien-Chie Hung | title = Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 | journal = Cancer Cell | volume = 6 | issue = 3 | pages = 251–61 | date = Sep 2004 | pmid = 15380516 | doi = 10.1016/j.ccr.2004.07.012 | doi-access = free }}
- {{cite journal | vauthors = Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K | title = A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 1 | pages = 377–85 | date = May 2006 | pmid = 16600182 | doi = 10.1016/j.bbrc.2006.03.071 }}
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