TPCN1

The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.{{cite journal | vauthors = Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y | title = Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana | journal = Nature | volume = 531 | issue = 7593 | pages = 196–201 | date = March 2016 | pmid = 26689363 | doi = 10.1038/nature16446 | pmc=4841471| bibcode = 2016Natur.531..196G }}{{cite journal | vauthors = Kintzer AF, Stroud RM | title = Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana | journal = Nature | volume = 531 | issue = 7593 | pages = 258–62 | date = March 2016 | pmid = 26961658 | doi = 10.1038/nature17194 | pmc=4863712| bibcode = 2016Natur.531..258K }} The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands. Only a single voltage sensor domain appears to responsible for voltage sensing.

Genetic knockout and pharmacological inhibition experiments demonstrate that the two-pore channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.{{cite journal | vauthors = Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA | title = Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment | journal = Science | volume = 347 | issue = 6225 | pages = 995–8 | date = February 2015 | pmid = 25722412 | doi = 10.1126/science.1258758 | pmc=4550587}}

• Two-pore channel

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• {{cite journal | vauthors = Ishibashi K, Suzuki M, Imai M | title = Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels | journal = Biochemical and Biophysical Research Communications | volume = 270 | issue = 2 | pages = 370–6 | date = April 2000 | pmid = 10753632 | doi = 10.1006/bbrc.2000.2435 }}
• {{cite journal | vauthors = Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O | title = Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain | journal = DNA Research | volume = 6 | issue = 5 | pages = 329–36 | date = October 1999 | pmid = 10574461 | doi = 10.1093/dnares/6.5.329 | doi-access = free }}
• {{cite journal | vauthors = Clapham DE, Garbers DL | title = International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 451–4 | date = December 2005 | pmid = 16382101 | doi = 10.1124/pr.57.4.7 | s2cid = 35096827 }}
• {{cite journal | vauthors = Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX | title = NAADP mobilizes calcium from acidic organelles through two-pore channels | journal = Nature | volume = 459 | issue = 7246 | pages = 596–600 | date = May 2009 | pmid = 19387438 | pmc = 2761823 | doi = 10.1038/nature08030 | bibcode = 2009Natur.459..596C }}
• {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = June 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | citeseerx = 10.1.1.500.923 }}

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• {{MeshName|TPCN1+protein,+human}}

{{Ion channels|g1}}

Category:Ion channels