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TPTE

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.{{cite journal | vauthors = Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE | title = The TPTE gene family: cellular expression, subcellular localization and alternative splicing | journal = Gene | volume = 323 | pages = 189–99 |date=Dec 2003 | pmid = 14659893 | doi =10.1016/j.gene.2003.09.038 }}{{cite web | title = Entrez Gene: TPTE transmembrane phosphatase with tensin homology| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7179}}

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids. TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase;{{cite journal | vauthors = Leslie NR, Yang X, Downes CP, Weijer CJ | title = PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration | journal = Curr. Biol. | volume = 17 | issue = 2 | pages = 115–25 |date=January 2007 | pmid = 17240336 | pmc = 1885949 | doi = 10.1016/j.cub.2006.12.026 }} TPTE itself is predicted to lack phosphatase activity.{{Cite journal|last1=Chen|first1=Mark J.|last2=Dixon|first2=Jack E.|last3=Manning|first3=Gerard|date=2017-04-11|title=Genomics and evolution of protein phosphatases|journal=Sci. Signal.|language=en|volume=10|issue=474|pages=eaag1796|doi=10.1126/scisignal.aag1796|issn=1945-0877|pmid=28400531|s2cid=41041971}} TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

References

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Further reading

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  • {{cite journal | author=Antonarakis SE |title=10 years of Genomics, chromosome 21, and Down syndrome. |journal=Genomics |volume=51 |issue= 1 |pages= 1–16 |year= 1998 |pmid= 9693027 |doi= 10.1006/geno.1998.5335 }}
  • {{cite journal |vauthors=Chen H, Rossier C, Morris MA, etal |title=A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. |journal=Hum. Genet. |volume=105 |issue= 5 |pages= 399–409 |year= 2000 |pmid= 10598804 |doi=10.1007/s004390051122 }}
  • {{cite journal |vauthors=Guipponi M, Yaspo ML, Riesselman L, etal |title=Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21. |journal=Hum. Genet. |volume=107 |issue= 2 |pages= 127–31 |year= 2000 |pmid= 11030409 |doi=10.1007/s004390000343 |s2cid=29304641 |url=http://doc.rero.ch/record/315699/files/439_2000_Article_343.pdf }}
  • {{cite journal |vauthors=Wu Y, Dowbenko D, Pisabarro MT, etal |title=PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21745–53 |year= 2001 |pmid= 11279206 |doi= 10.1074/jbc.M101480200 |doi-access= free }}
  • {{cite journal |vauthors=Guipponi M, Tapparel C, Jousson O, etal |title=The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. |journal=Hum. Genet. |volume=109 |issue= 6 |pages= 569–75 |year= 2002 |pmid= 11810268 |doi= 10.1007/s004390100607 |s2cid=8267495 |url=http://doc.rero.ch/record/321876/files/439_2014_Article_607.pdf }}

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{{Protein tyrosine phosphatases}}

{{gene-13-stub}}