TRA2A
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.{{cite journal | vauthors = Dauwalder B, Amaya-Manzanares F, Mattox W | title = A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 17 | pages = 9004–9 |date=Oct 1996 | pmid = 8799144 | pmc = 38585 | doi =10.1073/pnas.93.17.9004 | doi-access = free | bibcode = 1996PNAS...93.9004D }}{{cite journal | vauthors = Tacke R, Tohyama M, Ogawa S, Manley JL | title = Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing | journal = Cell | volume = 93 | issue = 1 | pages = 139–48 |date=May 1998 | pmid = 9546399 | doi =10.1016/S0092-8674(00)81153-8 | s2cid = 15384749 | doi-access = free }}{{cite web | title = Entrez Gene: TRA2A transformer-2 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29896}}
This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.
References
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Further reading
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- {{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 |doi-access= free }}
- {{cite journal | vauthors=Shin C, Feng Y, Manley JL |title=Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. |journal=Nature |volume=427 |issue= 6974 |pages= 553–8 |year= 2004 |pmid= 14765198 |doi= 10.1038/nature02288 |bibcode=2004Natur.427..553S |s2cid=4423246 }}
- {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Gevaert K, Staes A, Van Damme J, etal |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. |journal=Proteomics |volume=5 |issue= 14 |pages= 3589–99 |year= 2006 |pmid= 16097034 |doi= 10.1002/pmic.200401217 |s2cid=895879 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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