Login
Login

TRA2B

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.{{cite web | title = Entrez Gene: SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6434}}{{cite journal |vauthors=Nayler O, Cap C, Stamm S | title = Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform | journal = Genomics | volume = 53 | issue = 2 | pages = 191–202 |date=October 1998 | pmid = 9790768 | doi = 10.1006/geno.1998.5471 }}

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate.{{Cite journal |last=Karginov |first=Timofey A. |last2=Ménoret |first2=Antoine |last3=Leclair |first3=Nathan K. |last4=Harrison |first4=Andrew G. |last5=Chandiran |first5=Karthik |last6=Suarez-Ramirez |first6=Jenny E. |last7=Yurieva |first7=Marina |last8=Karlinsey |first8=Keaton |last9=Wang |first9=Penghua |last10=O’Neill |first10=Rachel J. |last11=Murphy |first11=Patrick A. |last12=Adler |first12=Adam J. |last13=Cauley |first13=Linda S. |last14=Anczuków |first14=Olga |last15=Zhou |first15=Beiyan |date=2024-09-13 |title=Autoregulated splicing of TRA2 β programs T cell fate in response to antigen-receptor stimulation |url=https://www.science.org/doi/10.1126/science.adj1979 |journal=Science |language=en |volume=385 |issue=6714 |doi=10.1126/science.adj1979 |issn=0036-8075|pmc=11697694 }}

Interactions

TRA2B has been shown to interact with RBMX.{{cite journal |last=Hofmann |first=Yvonne |author2=Wirth Brunhilde |date=Aug 2002 |title=hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1 |journal=Hum. Mol. Genet. |volume=11 |issue=17 |pages=2037–49 | issn = 0964-6906| pmid = 12165565 | doi=10.1093/hmg/11.17.2037|doi-access=free }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Matsuo N, Ogawa S, Imai Y, etal |title=Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28216–22 |year= 1996 |pmid= 7499316 |doi=10.1074/jbc.270.47.28216 |doi-access=free }}
  • {{cite journal |vauthors=Lennon G, Auffray C, Polymeropoulos M, Soares MB |title=The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. |journal=Genomics |volume=33 |issue= 1 |pages= 151–2 |year= 1996 |pmid= 8617505 |doi= 10.1006/geno.1996.0177 |doi-access= free }}
  • {{cite journal |vauthors=Beil B, Screaton G, Stamm S |title=Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. |journal=DNA Cell Biol. |volume=16 |issue= 6 |pages= 679–90 |year= 1997 |pmid= 9212162 |doi= 10.1089/dna.1997.16.679 }}
  • {{cite journal |vauthors=Imai Y, Matsuo N, Ogawa S, etal |title=Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1–2 |pages= 33–40 |year= 1998 |pmid= 9473574 |doi=10.1016/S0169-328X(97)00262-3 }}
  • {{cite journal |vauthors=Tacke R, Tohyama M, Ogawa S, Manley JL |title=Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. |journal=Cell |volume=93 |issue= 1 |pages= 139–48 |year= 1998 |pmid= 9546399 |doi=10.1016/S0092-8674(00)81153-8 |s2cid=15384749 |doi-access=free }}
  • {{cite journal |vauthors=Nayler O, Cap C, Stamm S |title=Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. |journal=Genomics |volume=53 |issue= 2 |pages= 191–202 |year= 1998 |pmid= 9790768 |doi= 10.1006/geno.1998.5471 }}
  • {{cite journal |vauthors=Eldridge AG, Li Y, Sharp PA, Blencowe BJ |title=The SRm160/300 splicing coactivator is required for exon-enhancer function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6125–30 |year= 1999 |pmid= 10339552 | pmc=26846 |doi=10.1073/pnas.96.11.6125 |bibcode=1999PNAS...96.6125E |doi-access=free }}
  • {{cite journal |vauthors=Lai MC, Lin RI, Huang SY, etal |title=A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7950–7 |year= 2000 |pmid= 10713112 |doi=10.1074/jbc.275.11.7950 |doi-access=free }}
  • {{cite journal |vauthors=Venables JP, Elliott DJ, Makarova OV, etal |title=RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. |journal=Hum. Mol. Genet. |volume=9 |issue= 5 |pages= 685–94 |year= 2000 |pmid= 10749975 |doi=10.1093/hmg/9.5.685 |doi-access=free }}
  • {{cite journal |vauthors=Helmken C, Wirth B |title=Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy. |journal=Hum. Genet. |volume=107 |issue= 6 |pages= 554–8 |year= 2001 |pmid= 11153908 |doi=10.1007/s004390000409 |s2cid=30528707 }}
  • {{cite journal |vauthors=Young PJ, DiDonato CJ, Hu D, etal |title=SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. |journal=Hum. Mol. Genet. |volume=11 |issue= 5 |pages= 577–87 |year= 2002 |pmid= 11875052 |doi=10.1093/hmg/11.5.577 |doi-access=free }}
  • {{cite journal |vauthors=Hofmann Y, Wirth B |title=hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1. |journal=Hum. Mol. Genet. |volume=11 |issue= 17 |pages= 2037–49 |year= 2003 |pmid= 12165565 |doi=10.1093/hmg/11.17.2037 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Tran Q, Coleman TP, Roesser JR |title=Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer. |journal=Biochim. Biophys. Acta |volume=1625 |issue= 2 |pages= 141–52 |year= 2003 |pmid= 12531473 |doi= 10.1016/S0167-4781(02)00600-0}}
  • {{cite journal |vauthors=El Yazidi-Belkoura I, Adriaenssens E, Dollé L, etal |title=Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16952–6 |year= 2003 |pmid= 12604596 |doi= 10.1074/jbc.M300631200 |url= http://prodinra.inra.fr/ft/12071604-E2B5-4987-80DF-D89AF5889D4B |doi-access= free }}
  • {{cite journal |vauthors=Jiang Z, Tang H, Havlioglu N, etal |title=Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 18997–9007 |year= 2003 |pmid= 12649279 | pmc=2140226 |doi= 10.1074/jbc.M301800200 |doi-access=free }}
  • {{cite journal |vauthors=Chen X, Guo L, Lin W, Xu P |title=Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern. |journal=Cell Biol. Int. |volume=27 |issue= 6 |pages= 491–6 |year= 2004 |pmid= 12798777 |doi=10.1016/S1065-6995(03)00072-6 |s2cid=44758770 }}
  • {{cite journal |vauthors=Helmken C, Hofmann Y, Schoenen F, etal |title=Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1. |journal=Hum. Genet. |volume=114 |issue= 1 |pages= 11–21 |year= 2004 |pmid= 14520560 |doi= 10.1007/s00439-003-1025-2 |s2cid=19872246 }}
  • {{cite journal |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 | pmc=207616 |doi=10.1128/MCB.23.21.7437-7447.2003 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}

{{refend}}

{{PDB Gallery|geneid=6434}}

{{gene-3-stub}}