TRAP1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.{{cite journal |vauthors=Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO | title = The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties | journal = J Biol Chem | volume = 275 | issue = 5 | pages = 3305–12 |date=March 2000 | pmid = 10652318 | doi =10.1074/jbc.275.5.3305 | doi-access = free }}{{cite journal |vauthors=Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB | title = Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor | journal = J Biol Chem | volume = 270 | issue = 8 | pages = 3574–81 |date=March 1995 | pmid = 7876093 | doi =10.1074/jbc.270.8.3574 | doi-access = free }}{{cite web | title = Entrez Gene: TRAP1 TNF receptor-associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10131}}
Interactions
TRAP1 has been shown to interact with EXT2,{{cite journal |last=Simmons |first=A D |author2=Musy M M |author3=Lopes C S |author4=Hwang L Y |author5=Yang Y P |author6=Lovett M |date=November 1999 |title=A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses |journal=Hum. Mol. Genet. |volume=8 |issue=12 |pages=2155–64 | issn = 0964-6906| pmid = 10545594 |doi=10.1093/hmg/8.12.2155 |doi-access=free }} EXT1 and Retinoblastoma protein.{{cite journal |last=Chen |first=C F |author2=Chen Y |author3=Dai K |author4=Chen P L |author5=Riley D J |author6=Lee W H |date=September 1996 |title=A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock |journal=Mol. Cell. Biol. |volume=16 |issue=9 |pages=4691–9 | issn = 0270-7306| pmid = 8756626 |pmc=231469 |doi=10.1128/MCB.16.9.4691 }}
References
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Further reading
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- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | author=Chen CF |title=A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4691–9 |year= 1996 |pmid= 8756626 |doi= 10.1128/MCB.16.9.4691| pmc=231469 |name-list-style=vanc| author2=Chen Y | author3=Dai K | display-authors=3 | last4=Chen | first4=PL | last5=Riley | first5=DJ | last6=Lee | first6=WH }}
- {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
- {{cite journal |vauthors=Charng MJ, Zhang D, Kinnunen P, Schneider MD |title=A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9365–8 |year= 1998 |pmid= 9545258 |doi=10.1074/jbc.273.16.9365 |doi-access=free }}
- {{cite journal | author=Simmons AD |title=A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses |journal=Hum. Mol. Genet. |volume=8 |issue= 12 |pages= 2155–64 |year= 1999 |pmid= 10545594 |doi=10.1093/hmg/8.12.2155 |name-list-style=vanc| author2=Musy MM | author3=Lopes CS | display-authors=3 | last4=Hwang | first4=LY | last5=Yang | first5=YP | last6=Lovett | first6=M | doi-access=free }}
- {{cite journal | author=Wurthner JU |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495–502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200 |name-list-style=vanc| author2=Frank DB | author3=Felici A | display-authors=3 | last4=Green | first4=HM | last5=Cao | first5=Z | last6=Schneider | first6=MD | last7=McNally | first7=JG | last8=Lechleider | first8=RJ | last9=Roberts | first9=AB | doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Masuda Y |title=Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42503–15 |year= 2004 |pmid= 15292218 |doi= 10.1074/jbc.M404256200 |name-list-style=vanc| author2=Shima G | author3=Aiuchi T | display-authors=3 | last4=Horie | first4=M | last5=Hori | first5=K | last6=Nakajo | first6=S | last7=Kajimoto | first7=S | last8=Shibayama-Imazu | first8=T | last9=Nakaya | first9=K | doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Brown V |title=Binding specificity of Toll-like receptor cytoplasmic domains |journal=Eur. J. Immunol. |volume=36 |issue= 3 |pages= 742–53 |year= 2006 |pmid= 16482509 |doi= 10.1002/eji.200535158 | pmc=2762736 |name-list-style=vanc| author2=Brown RA | author3=Ozinsky A | display-authors=3 | last4=Hesselberth | first4=Jay R. | last5=Fields | first5=Stanley }}
- {{cite journal |vauthors=Im CN, Lee JS, Zheng Y, Seo JS |title=Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species |journal=J. Cell. Biochem. |volume=100 |issue= 2 |pages= 474–86 |year= 2007 |pmid= 16927372 |doi= 10.1002/jcb.21064 |s2cid=12489077 }}
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External links
- {{UCSC genome browser|TRAP1}}
- {{UCSC gene details|TRAP1}}
{{Chaperones}}
{{gene-16-stub}}