TRAPPC10
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.{{cite journal |vauthors=Yamakawa K, Mitchell S, Hubert R, Chen XN, Colbern S, Huo YK, Gadomski C, Kim UJ, Korenberg JR | title = Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3 | journal = Hum Mol Genet | volume = 4 | issue = 4 | pages = 709–16 |date=Sep 1995 | pmid = 7633421 | doi =10.1093/hmg/4.4.709 }}{{cite web | title = Entrez Gene: TMEM1 transmembrane protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7109}}
The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi.
Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.
References
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Further reading
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- {{cite journal | author=Nagamine K |title=Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3 |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 185–90 |year= 1997 |pmid= 9196060 |doi= 10.1006/bbrc.1997.6758 |name-list-style=vanc| author2=Kudoh J | author3=Kawasaki K | display-authors=3 | last4=Minoshima | first4=Shinsei | last5=Asakawa | first5=Shuichi | last6=Ito | first6=Fumiaki | last7=Shimizu | first7=Nobuyoshi }}
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- {{cite journal | author=Gavin AC |title=Functional organization of the yeast proteome by systematic analysis of protein complexes |journal=Nature |volume=415 |issue= 6868 |pages= 141–7 |year= 2002 |pmid= 11805826 |doi= 10.1038/415141a |name-list-style=vanc| author2=Bösche M | author3=Krause R | display-authors=3 | last4=Grandi | first4=Paola | last5=Marzioch | first5=Martina | last6=Bauer | first6=Andreas | last7=Schultz | first7=Jörg | last8=Rick | first8=Jens M. | last9=Michon | first9=Anne-Marie |bibcode=2002Natur.415..141G |s2cid=4425555 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |name-list-style=vanc| author2=Jedrychowski M | author3=Schwartz D | display-authors=3 | last4=Elias | first4=JE | last5=Villén | first5=J | last6=Li | first6=J | last7=Cohn | first7=MA | last8=Cantley | first8=LC | last9=Gygi | first9=SP |bibcode=2004PNAS..10112130B |doi-access=free }}
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