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TRERF1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.{{cite journal | vauthors = Gizard F, Lavallée B, DeWitte F, Hum DW | title = A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 36 | pages = 33881–92 | date = September 2001 | pmid = 11349124 | doi = 10.1074/jbc.M100113200 | doi-access = free }}{{cite web | title = Entrez Gene: TRERF1 transcriptional regulating factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55809}}

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.{{cite web | title = Entrez Gene: TRERF1 transcriptional regulating factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55809}}

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,{{cite journal | vauthors = Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW | title = The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39144–55 | date = October 2002 | pmid = 12101186 | doi = 10.1074/jbc.M205786200 | doi-access = free }} EP300 and CREB-binding protein.

References

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Further reading

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  • {{cite journal | vauthors = Dorssers LC, Veldscholte J | title = Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells | journal = International Journal of Cancer | volume = 72 | issue = 4 | pages = 700–5 | date = August 1997 | pmid = 9259413 | doi = 10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D | s2cid = 29607511 | doi-access = free }}
  • {{cite journal | vauthors = Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW | title = The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39144–55 | date = October 2002 | pmid = 12101186 | doi = 10.1074/jbc.M205786200 | doi-access = free }}
  • {{cite journal | vauthors = Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, Beatty BG, Hum DW | display-authors = 6 | title = Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression | journal = Endocrine Research | volume = 28 | issue = 4 | pages = 559–74 | date = November 2002 | pmid = 12530663 | doi = 10.1081/ERC-120016841 | s2cid = 22485023 }}
  • {{cite journal | vauthors = Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW | title = The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells | journal = Journal of Molecular Endocrinology | volume = 32 | issue = 2 | pages = 557–69 | date = April 2004 | pmid = 15072559 | doi = 10.1677/jme.0.0320557 | doi-access = free }}
  • {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | display-authors = 6 | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
  • {{cite journal | vauthors = Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, Peyrat JP, Staels B, Hum DW | display-authors = 6 | title = TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1 | journal = Molecular and Cellular Biology | volume = 25 | issue = 11 | pages = 4335–48 | date = June 2005 | pmid = 15899840 | pmc = 1140623 | doi = 10.1128/MCB.25.11.4335-4348.2005 }}
  • {{cite journal | vauthors = Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, Torpier G, Hum DW, Staels B | display-authors = 6 | title = TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone | journal = Molecular and Cellular Biology | volume = 26 | issue = 20 | pages = 7632–44 | date = October 2006 | pmid = 17015480 | pmc = 1636875 | doi = 10.1128/MCB.00326-06 }}

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