TRIB3

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.{{cite journal |vauthors= Eyers PA, Keeshan K, Kannan N | title = Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease. | journal = Trends in Cell Biology | volume = 27 | issue = 9 | pages = S0962-8924(16)30178-7 | year = 2016 | pmid = 27908682 | doi = 10.1016/j.tcb.2016.11.002| pmc=5382568}}{{cite journal |vauthors= Foulkes DM, Byrne DP, Eyers PA | title = Tribbles pseudokinases: novel targets for chemical biology and drug discovery? | journal = Biochemical Society Transactions | volume = 43 | issue = 5 | pages = 1095–1103 | year = 2015 | pmid = 26517930 | doi = 10.1042/BST20150109}}

TRIB3 has been shown to interact with:

• AKT1,
• CSNK2B,{{cite journal |vauthors=Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F | title = E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3 | journal = Cell. Signal. | volume = 20 | issue = 5 | pages = 942–8 |date=May 2008 | pmid = 18276110 | doi = 10.1016/j.cellsig.2008.01.010 }}
• Fibronectin
• MCM3AP,{{cite journal |vauthors=Bowers AJ, Scully S, Boylan JF | title = SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia | journal = Oncogene | volume = 22 | issue = 18 | pages = 2823–35 |date=May 2003 | pmid = 12743605 | doi = 10.1038/sj.onc.1206367 | doi-access = free }}
• RELA,{{cite journal |vauthors=Wu M, Xu LG, Zhai Z, Shu HB | title = SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 27072–9 |date=July 2003 | pmid = 12736262 | doi = 10.1074/jbc.M209814200 | doi-access = free}}
• SIAH1, and
• TIAF1.

{{reflist}}

{{refbegin | 2}}

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• {{cite journal |vauthors=Ohoka N, Yoshii S, Hattori T, etal |title=TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1243–55 |year= 2005 |pmid= 15775988 |doi= 10.1038/sj.emboj.7600596 | pmc=556400 }}
• {{cite journal |vauthors=Ord D, Ord T |title=Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 210–8 |year= 2005 |pmid= 15781252 |doi= 10.1016/j.bbrc.2005.02.149 }}
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• {{cite journal |vauthors=Schwarzer R, Dames S, Tondera D, etal |title=TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. |journal=Cell. Signal. |volume=18 |issue= 6 |pages= 899–909 |year= 2006 |pmid= 16129579 |doi= 10.1016/j.cellsig.2005.08.002 }}
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• {{cite journal |vauthors=Matsushima R, Harada N, Webster NJ, etal |title=Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 29719–29 |year= 2006 |pmid= 16887816 |doi= 10.1074/jbc.M511636200 |doi-access= free }}
• {{cite journal |vauthors=Koh HJ, Arnolds DE, Fujii N, etal |title=Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. |journal=Mol. Cell. Biol. |volume=26 |issue= 22 |pages= 8217–27 |year= 2007 |pmid= 16966378 |doi= 10.1128/MCB.00979-06 | pmc=1636784 }}

{{refend}}

{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

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