TRIM16
{{Short description|Gene of the species Homo sapiens}}
{{Infobox_gene}}
Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.{{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = EMBO J | volume = 20 | issue = 9 | pages = 2140–51 |date=May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}{{cite web | title = Entrez Gene: TRIM16 tripartite motif-containing 16| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10626| accessdate = }}
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.
The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
References
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Further reading
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- {{cite journal |vauthors=Liu HL, Golder-Novoselsky E, Seto MH, etal |title=The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant |journal=Mol. Endocrinol. |volume=12 |issue= 11 |pages= 1733–48 |year= 1999 |pmid= 9817599 |doi=10.1210/mend.12.11.0193 |doi-access=free }}
- {{cite journal |vauthors=Beer HD, Munding C, Dubois N, etal |title=The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20740–9 |year= 2002 |pmid= 11919186 |doi= 10.1074/jbc.M111233200 |doi-access= free |hdl= 20.500.11850/91604 |hdl-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Munding C, Keller M, Niklaus G, etal |title=The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion |journal=Cell Death Differ. |volume=13 |issue= 11 |pages= 1938–49 |year= 2006 |pmid= 16575408 |doi= 10.1038/sj.cdd.4401896 |s2cid=8953820 }}
- {{cite journal |vauthors=Cheung BB, Bell J, Raif A, etal |title=The estrogen-responsive B box protein is a novel regulator of the retinoid signal |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 18246–56 |year= 2006 |pmid= 16636064 |doi= 10.1074/jbc.M600879200 |doi-access= free }}
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