TRIM6
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.{{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = EMBO J | volume = 20 | issue = 9 | pages = 2140–51 |date=May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}{{cite web | title = Entrez Gene: TRIM6 tripartite motif-containing 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117854| accessdate = }}
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.
References
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Further reading
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- {{cite journal |vauthors=Li X, Gold B, O'hUigin C, etal |title=Unique features of TRIM5alpha among closely related human TRIM family members. |journal=Virology |volume=360 |issue= 2 |pages= 419–33 |year= 2007 |pmid= 17156811 |doi= 10.1016/j.virol.2006.10.035 |doi-access= free }}
- {{cite journal |vauthors=Zhang F, Hatziioannou T, Perez-Caballero D, etal |title=Antiretroviral potential of human tripartite motif-5 and related proteins. |journal=Virology |volume=353 |issue= 2 |pages= 396–409 |year= 2006 |pmid= 16828831 |doi= 10.1016/j.virol.2006.05.035 |doi-access= free }}
- {{cite journal |vauthors=Li X, Li Y, Stremlau M, etal |title=Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. |journal=J. Virol. |volume=80 |issue= 13 |pages= 6198–206 |year= 2006 |pmid= 16775307 |doi= 10.1128/JVI.00283-06 | pmc=1488960 }}
- {{cite journal |vauthors=Woo JS, Imm JH, Min CK, etal |title=Structural and functional insights into the B30.2/SPRY domain. |journal=EMBO J. |volume=25 |issue= 6 |pages= 1353–63 |year= 2006 |pmid= 16498413 |doi= 10.1038/sj.emboj.7600994 | pmc=1422157 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Orimo A, Tominaga N, Yoshimura K, etal |title=Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. |journal=Genomics |volume=69 |issue= 1 |pages= 143–9 |year= 2001 |pmid= 11013086 |doi= 10.1006/geno.2000.6318 }}
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