TRMU
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.{{cite journal |vauthors=Yan Q, Guan MX | title = Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase | journal = Biochim Biophys Acta | volume = 1676 | issue = 2 | pages = 119–26 |date=Jan 2004 | pmid = 14746906 | doi = 10.1016/j.bbaexp.2003.11.010}}{{cite web | title = Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55687}}
This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.
References
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Further reading
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- {{cite journal | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |name-list-style=vanc| author2=Shimizu N | author3=Roe BA | display-authors=3 | last4=Bruskiewich | first4=R. | last5=Beare | first5=D. M. | last6=Clamp | first6=M. | last7=Smink | first7=L. J. | last8=Ainscough | first8=R. | last9=Almeida | first9=J. P. |bibcode=1999Natur.402..489D | doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-style=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera |doi-access=free }}
- {{cite journal | author=Umeda N |title=Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1613–24 |year= 2005 |pmid= 15509579 |doi= 10.1074/jbc.M409306200 |name-list-style=vanc| author2=Suzuki T | author3=Yukawa M | display-authors=3 | last4=Ohya | first4=Y | last5=Shindo | first5=H | last6=Watanabe | first6=K | last7=Suzuki | first7=T | doi-access=free }}
- {{cite journal |vauthors=Yan Q, Li X, Faye G, Guan MX |title=Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29151–7 |year= 2005 |pmid= 15944150 | pmc=2905382 |doi= 10.1074/jbc.M504247200 |doi-access=free }}
- {{cite journal | author=Oh JH |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |name-list-style=vanc| author2=Yang JO | author3=Hahn Y | display-authors=3 | last4=Kim | first4=Mi-Rang | last5=Byun | first5=Sang-Soon | last6=Jeon | first6=Yeo-Jin | last7=Kim | first7=Jeong-Min | last8=Song | first8=Kyu-Sang | last9=Noh | first9=Seung-Moo |s2cid=69278 }}
- {{cite journal | author=Yan Q |title=Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1130–6 |year= 2006 |pmid= 16513084 |doi= 10.1016/j.bbrc.2006.02.078 |name-list-style=vanc| author2=Bykhovskaya Y | author3=Li R | display-authors=3 | last4=Mengesha | first4=Emebet | last5=Shohat | first5=Mordechai | last6=Estivill | first6=Xavier | last7=Fischel-Ghodsian | first7=Nathan | last8=Guan | first8=Min-Xin }}
- {{cite journal | author=Guan MX |title=Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 291–302 |year= 2006 |pmid= 16826519 |doi= 10.1086/506389 | pmc=1559489 |name-list-style=vanc| author2=Yan Q | author3=Li X | display-authors=3 | last4=Bykhovskaya | first4=Yelena | last5=Gallo-Teran | first5=Jaime | last6=Hajek | first6=Petr | last7=Umeda | first7=Noriko | last8=Zhao | first8=Hui | last9=Garrido | first9=Gema }}
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