TRNA-pseudouridine synthase I
{{infobox enzyme
| Name = tRNA-pseudouridine synthase
| EC_number = 5.4.99.12
| CAS_number =
| GO_code = 0016439
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| width =
| caption =
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{{lowercase title}}
In enzymology, a tRNA-pseudouridine synthase I ({{EnzExplorer|5.4.99.12}}) is an enzyme that catalyzes the chemical reaction
:tRNA uridine tRNA pseudouridine
Hence, this enzyme has one substrate, tRNA uridine, and one product, tRNA pseudouridine.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1VS3}}, {{PDB link|2NQP}}, {{PDB link|2NR0}}, and {{PDB link|2NRE}}.
References
{{reflist|1}}
- {{cite journal | vauthors = Arena F, Ciliberto G, Ciampi S, Cortese R | date = 1978 | title = Purification of pseudouridylate synthetase I from Salmonella typhimurium | journal = Nucleic Acids Res. | volume = 5 | pages = 4523–36 | pmid = 370771 | doi = 10.1093/nar/5.12.4523 | issue = 12 | pmc = 342770 }}
- {{cite journal | vauthors = Kammen HO, Marvel CC, Hardy L, Penhoet EE | date = 1988 | title = Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I | journal = J. Biol. Chem. | volume = 263 | pages = 2255–63 | pmid = 3276686 | issue = 5 | doi = 10.1016/S0021-9258(18)69199-9 | doi-access = free }}
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Category:Enzymes of known structure
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