TRPM4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.{{cite journal | vauthors = Xu XZ, Moebius F, Gill DL, Montell C | title = Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 19 | pages = 10692–7 |date=September 2001 | pmid = 11535825 | pmc = 58528 | doi = 10.1073/pnas.191360198 | doi-access = free | bibcode = 2001PNAS...9810692X }}{{cite journal | vauthors = Clapham DE, Julius D, Montell C, Schultz G | title = International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 427–50 |date=December 2005 | pmid = 16382100 | doi = 10.1124/pr.57.4.6 | s2cid = 17936350 }}
TRPM4 Channel Blocker
See also
References
{{Reflist}}
Further reading
{{refbegin | 2}}
- {{cite book | last = Islam | first = Md. Shahidul | title = Transient Receptor Potential Channels |date=January 2011 | volume = 704 | publisher = Springer | location = Berlin | pages = 700 | series = Advances in Experimental Medicine and Biology | isbn = 978-94-007-0264-6 }}
- {{cite journal | vauthors=Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP |title=TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization |journal=Cell |volume= 109|issue= 3 |pages= 397–407 |year= 2002 |pmid= 12015988 |doi= 10.1016/S0092-8674(02)00719-5 |s2cid=14411824 |doi-access= free }}
- {{cite journal | vauthors=Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP |title=TRPM4 regulates calcium oscillations after T cell activation |journal=Science |volume= 306 |issue= 5700 |pages= 1374–1377 |year= 2004 |pmid= 15550671 |doi= 10.1126/science.1098845 |bibcode=2004Sci...306.1374L |s2cid=16459097 }}
- {{cite book | vauthors=Vennekens R, Nilius B |title=Transient Receptor Potential (TRP) Channels |chapter=Insights into TRPM4 function, regulation and physiological role |volume= 179|issue= |pages= 269–85 |year= 2007 |pmid= 17217063 |doi= 10.1007/978-3-540-34891-7_16 | series=Handbook of Experimental Pharmacology | isbn=978-3-540-34889-4 }}
- {{cite journal | vauthors=Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M |title=Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4 |journal=Nat Immunol |volume= 8 |issue= 3 |pages= 312–320 |year= 2007 |pmid= 17293867 |doi= 10.1038/ni1441 |s2cid=29303898 |url= https://lirias.kuleuven.be/bitstream/123456789/44883/2/Nature+Immunology+Mast+Cell.pdf }}
- {{cite journal | vauthors=Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P |title=The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells |journal=Nat Immunol |volume= 9 |issue= 10 |pages= 1148–56 |year= 2008 |pmid= 18758465 |doi= 10.1038/ni.1648 | pmc=2956271 }}
{{refend}}
External links
- {{MeshName|TRPM4+protein,+human}}
{{NLM content}}
{{Ion channels|g4}}
{{Transient receptor potential channel modulators}}
{{membrane-protein-stub}}