TRPM7

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.{{cite web | title = Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54822}}

TRPM7 has been shown to interact with PLCB1{{cite journal | vauthors = Runnels LW, Yue L, Clapham DE | title = The TRPM7 channel is inactivated by PIP(2) hydrolysis | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 329–36 | date = May 2002 | pmid = 11941371 | doi = 10.1038/ncb781 | s2cid = 21592843 }} and PLCB2.

Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.{{cite journal | vauthors = Vargas-Poussou R, Claverie-Martin F, Prot-Bertoye C, Carotti V, van der Wijst J, Perdomo-Ramirez A, Fraga-Rodriguez GM, Hureaux M, Bos C, Latta F, Houillier P, Hoenderop JG, de Baaij JH | title = Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia | journal = Nephrology Dialysis Transplantation | volume = 38 | issue = 3 | pages = 679–690 | year = 2023 | pmid = 35561741 | doi = 10.1093/ndt/gfac182 | pmc = 9976740 }}{{cite journal | vauthors = Bosman W, Butler KM, Chang CA, Ganapathi M, Guzman E, Latta F, Chung WK, Claverie-Martin F, Davis JM, Hoenderop JG, de Baaij JH | title = Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay | journal = Clinical Kidney Journal | volume = sfae211 | year = 2024 | issue = 8 | pages = sfae211 | doi = 10.1093/ckj/sfae211 | doi-access = free | pmid = 39099563 | pmc = 11295107 }}

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.{{cite journal | vauthors = Baldoli E, Maier JA | title = Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells | journal = Angiogenesis | volume = 15 | issue = 1 | pages = 47–57 | year = 2012 | pmid = 22183257 | doi = 10.1007/s10456-011-9242-0 | s2cid = 16274084 }}

• TRPM

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• {{cite journal | vauthors = Chubanov V, Gudermann T, Schlingmann KP | title = Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis | journal = Pflügers Arch. | volume = 451 | issue = 1 | pages = 228–34 | year = 2005 | pmid = 16075242 | doi = 10.1007/s00424-005-1470-y | s2cid = 6037803 }}
• {{cite journal | vauthors = Clapham DE, Julius D, Montell C, Schultz G | title = International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 427–50 | year = 2005 | pmid = 16382100 | doi = 10.1124/pr.57.4.6 | s2cid = 17936350 }}
• {{cite book | vauthors = Penner R, Fleig A | title = Transient Receptor Potential (TRP) Channels | chapter = The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7 | series = Handbook of Experimental Pharmacology | volume = 179 | issue = 179 | pages = 313–28 | year = 2007 | pmid = 17217066 | doi = 10.1007/978-3-540-34891-7_19 | pmc = 5663631 | isbn = 978-3-540-34889-4 }}

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• {{MeshName|TRPM7+protein,+human}}

{{NLM content}}

{{PDB Gallery|geneid=54822}}

{{Ion channels|g4}}

{{Transient receptor potential channel modulators}}

Category:Ion channels

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