TSPAN2
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.{{cite journal |vauthors=Todd SC, Doctor VS, Levy S | title = Sequences and expression of six new members of the tetraspanin/TM4SF family | journal = Biochim Biophys Acta | volume = 1399 | issue = 1 | pages = 101–4 |date=Sep 1998 | pmid = 9714763 | doi = 10.1016/s0167-4781(98)00087-6| doi-access = free }}{{cite journal | author = Berditchevski F | title = Complexes of tetraspanins with integrins: more than meets the eye | journal = J Cell Sci | volume = 114 | issue = Pt 23 | pages = 4143–51 |date=Dec 2001 | doi = 10.1242/jcs.114.23.4143 | pmid = 11739647 }}{{cite web | title = Entrez Gene: TSPAN2 tetraspanin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10100}}
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
References
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Further reading
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- {{cite journal | author=Hemler ME |title=Specific tetraspanin functions |journal=J. Cell Biol. |volume=155 |issue= 7 |pages= 1103–7 |year= 2002 |pmid= 11756464 |doi= 10.1083/jcb.200108061 | pmc=2199333 }}
- {{cite journal | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 | author2=Barlow KF | author3=McLay KE | display-authors=3 | last4=Kaul | first4=R. | last5=Swarbreck | first5=D. | last6=Dunham | first6=A. | last7=Scott | first7=C. E. | last8=Howe | first8=K. L. | last9=Woodfine | first9=K. |bibcode=2006Natur.441..315G | doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
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External links
- {{UCSC genome browser|TSPAN2}}
- {{UCSC gene details|TSPAN2}}
{{Membrane proteins}}
{{gene-1-stub}}