TSPAN4
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | journal = J Biol Chem | volume = 272 | issue = 46 | pages = 29181–9 |date=Dec 1997 | pmid = 9360996 | doi =10.1074/jbc.272.46.29181 | doi-access = free }}{{cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106}}
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
Interactions
References
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Further reading
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- {{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |doi=10.1242/jcs.114.23.4143 |pmid= 11739647 }}
- {{cite journal | vauthors=Todd SC, Doctor VS, Levy S |title=Sequences and expression of six new members of the tetraspanin/TM4SF family. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 101–4 |year= 1998 |pmid= 9714763 |doi= 10.1016/s0167-4781(98)00087-6|doi-access=free }}
- {{cite journal |vauthors=Serru V, Le Naour F, Billard M, etal |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. | volume=340 |journal=Biochem. J. |issue= 1|pages= 103–11 |year= 1999 |pmid= 10229664 |doi=10.1042/0264-6021:3400103 | pmc=1220227 }}
- {{cite journal |vauthors=Yauch RL, Kazarov AR, Desai B, etal |title=Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9230–8 |year= 2000 |pmid= 10734060 |doi=10.1074/jbc.275.13.9230 |doi-access=free }}
- {{cite journal |vauthors=Lozahic S, Christiansen D, Manié S, etal |title=CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 900–7 |year= 2000 |pmid= 10741407 |doi= 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X |doi-access= free }}
- {{cite journal |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Clark AG, Glanowski S, Nielsen R, etal |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 |bibcode=2003Sci...302.1960C |s2cid=6682593 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 }}
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{{Cell membrane proteins}}
{{gene-11-stub}}