TTC8

TTC8 is associated with gamma-tubulin, BBS4, and PCM1 in the centrosome. PCM1 in turn is involved in centriolar replication during ciliogenesis.{{cite journal | vauthors = Kubo A, Sasaki H, Yuba-Kubo A, Tsukita S, Shiina N | title = Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis | journal = J. Cell Biol. | volume = 147 | issue = 5 | pages = 969–80 |date=November 1999 | pmid = 10579718 | pmc = 2169353 | doi = 10.1083/jcb.147.5.969 }}

TTC8 is located in the cilia of spermatids, retina, and bronchial epithelium cells.

Mutations in the TTC8 gene is one of 14 genes

{{cite web |last=Hamosh|first=Ada |title=OMIM entry #209900 Bardet-Biedl Syndrome; BBS|url=http://omim.org/entry/209900 |date=2012-11-02 |work=Online Mendelian Inheritance in Man |publisher=McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine |access-date=2013-09-04}}

identified as causal for Bardet–Biedl syndrome.{{cite journal | vauthors = Stoetzel C, Laurier V, Faivre L, Mégarbané A, Perrin-Schmitt F, Verloes A, Bonneau D, Mandel JL, Cossee M, Dollfus H | title = BBS8 is rarely mutated in a cohort of 128 Bardet-Biedl syndrome families | journal = J. Hum. Genet. | volume = 51 | issue = 1 | pages = 81–4 | year = 2006 | pmid = 16308660 | doi = 10.1007/s10038-005-0320-2 | doi-access = free }}

{{Reflist|2}}

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• {{cite journal |vauthors=Nachury MV, Loktev AV, Zhang Q, et al |title=A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. |journal=Cell |volume=129 |issue= 6 |pages= 1201–13 |year= 2007 |pmid= 17574030 |doi= 10.1016/j.cell.2007.03.053 |doi-access= free }}
• {{cite journal |vauthors=Chung WK, Patki A, Matsuoka N, et al |title=Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. |journal=Hum. Hered. |volume=67 |issue= 3 |pages= 193–205 |year= 2009 |pmid= 19077438 |pmc=2715950 |doi= 10.1159/000181158 }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, et al |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |pmc=528928 |doi= 10.1101/gr.2596504 }}
• {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, et al |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
• {{cite journal |vauthors=Riazuddin SA, Iqbal M, Wang Y, et al |title=A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa. |journal=Am. J. Hum. Genet. |volume=86 |issue= 5 |pages= 805–12 |year= 2010 |pmid= 20451172 |pmc=2869005 |doi= 10.1016/j.ajhg.2010.04.001 }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Bin J, Madhavan J, Ferrini W, et al |title=BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population. |journal=Hum. Mutat. |volume=30 |issue= 7 |pages= E737–46 |year= 2009 |pmid= 19402160 |doi= 10.1002/humu.21040 |doi-access= |s2cid=11446097 }}

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• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=bbs GeneReviews/NIH/NCBI/UW entry on Bardet–Biedl Syndrome] a
• {{MeSH name|TTC8+protein,+human|3=TTC8 protein, human}}

{{Ciliary proteins}}

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